Synthesis and in Vitro Antimicrobial Evaluation of Novel Potent Bioactive Heterocyclic Compounds

Abstract

In the present work, the antibacterial and antifungal properties of six new heterocyclic Schiff bases (HSb₁, HSb₂, HSb₃, HSb₄, HSb₅, HSb₆) were evaluated as potential bioactive compounds against the disease-causing pathogenic microorganisms (S.epidermidis, S.aureus, B.cereus RSKK863, E.aerogenes, P.aeroginosa sp., K. pneumonia, S. type H, P.vulgaris, E. coli and (C.albicans Y-1200-NIH). The well-diffusion-method was used to determine the antimicrobial activity. For this purpose, heterocyclic Schiff bases were synthesized by condensation reaction of aldehyde derivatives and thiosemicarbazide derivatives. Spectral analysis techniques (organic elemental analysis, FT-IR,¹H-NMR, HRMS, SEM-EDX) were used to characterize the synthesized compounds. It was determined that all the newly synthesized heterocyclic Schiff bases exhibited sound, high or moderate inhibitory effects on the growth of selected different standard antibiotics.