Electrochemical sensors for analyte in saliva: recent update

IF 1.6 4区工程技术 Q3 INSTRUMENTS & INSTRUMENTATION

Sensor Review Pub Date : 2024-01-01 DOI:10.1108/sr-06-2023-0202

Xingxing Li, Shixi You, Zengchang Fan, Guangjun Li, Li Fu

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引用次数: 0

Abstract

Purpose

This review provides an overview of recent advances in electrochemical sensors for analyte detection in saliva, highlighting their potential applications in diagnostics and health care. The purpose of this paper is to summarize the current state of the field, identify challenges and limitations and discuss future prospects for the development of saliva-based electrochemical sensors.

Design/methodology/approach

The paper reviews relevant literature and research articles to examine the latest developments in electrochemical sensing technologies for saliva analysis. It explores the use of various electrode materials, including carbon nanomaterial, metal nanoparticles and conducting polymers, as well as the integration of microfluidics, lab-on-a-chip (LOC) devices and wearable/implantable technologies. The design and fabrication methodologies used in these sensors are discussed, along with sample preparation techniques and biorecognition elements for enhancing sensor performance.

Findings

Electrochemical sensors for salivary analyte detection have demonstrated excellent potential for noninvasive, rapid and cost-effective diagnostics. Recent advancements have resulted in improved sensor selectivity, stability, sensitivity and compatibility with complex saliva samples. Integration with microfluidics and LOC technologies has shown promise in enhancing sensor efficiency and accuracy. In addition, wearable and implantable sensors enable continuous, real-time monitoring of salivary analytes, opening new avenues for personalized health care and disease management.

Originality/value

This review presents an up-to-date overview of electrochemical sensors for analyte detection in saliva, offering insights into their design, fabrication and performance. It highlights the originality and value of integrating electrochemical sensing with microfluidics, wearable/implantable technologies and point-of-care testing platforms. The review also identifies challenges and limitations, such as interference from other saliva components and the need for improved stability and reproducibility. Future prospects include the development of novel microfluidic devices, advanced materials and user-friendly diagnostic devices to unlock the full potential of saliva-based electrochemical sensing in clinical practice.

查看原文本刊更多论文

唾液中分析物的电化学传感器：最新进展

目的本综述概述了用于检测唾液中分析物的电化学传感器的最新进展，重点介绍了这些传感器在诊断和医疗保健领域的潜在应用。本文旨在总结该领域的现状，确定挑战和局限性，并讨论基于唾液的电化学传感器的未来发展前景。本文回顾了相关文献和研究文章，研究了用于唾液分析的电化学传感技术的最新进展。论文探讨了各种电极材料的使用，包括碳纳米材料、金属纳米颗粒和导电聚合物，以及微流控、片上实验室（LOC）设备和可穿戴/可植入技术的整合。研究结果用于唾液分析物检测的电化学传感器在无创、快速和经济高效的诊断方面表现出了巨大的潜力。最近的进步提高了传感器的选择性、稳定性、灵敏度以及与复杂唾液样本的兼容性。与微流控技术和 LOC 技术的整合有望提高传感器的效率和准确性。此外，可穿戴和植入式传感器可实现对唾液分析物的连续、实时监测，为个性化医疗保健和疾病管理开辟了新途径。它强调了将电化学传感与微流控、可穿戴/可植入技术和床旁检测平台相结合的独创性和价值。综述还指出了所面临的挑战和局限性，如唾液中其他成分的干扰，以及提高稳定性和可重复性的必要性。未来的前景包括开发新型微流控装置、先进材料和用户友好型诊断设备，以充分挖掘基于唾液的电化学传感在临床实践中的潜力。

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来源期刊

Sensor Review 工程技术-仪器仪表

CiteScore

3.40

自引率

6.20%

发文量

审稿时长

3.7 months

期刊介绍： Sensor Review publishes peer reviewed state-of-the-art articles and specially commissioned technology reviews. Each issue of this multidisciplinary journal includes high quality original content covering all aspects of sensors and their applications, and reflecting the most interesting and strategically important research and development activities from around the world. Because of this, readers can stay at the very forefront of high technology sensor developments. Emphasis is placed on detailed independent regular and review articles identifying the full range of sensors currently available for specific applications, as well as highlighting those areas of technology showing great potential for the future. The journal encourages authors to consider the practical and social implications of their articles. All articles undergo a rigorous double-blind peer review process which involves an initial assessment of suitability of an article for the journal followed by sending it to, at least two reviewers in the field if deemed suitable. Sensor Review’s coverage includes, but is not restricted to: Mechanical sensors – position, displacement, proximity, velocity, acceleration, vibration, force, torque, pressure, and flow sensors Electric and magnetic sensors – resistance, inductive, capacitive, piezoelectric, eddy-current, electromagnetic, photoelectric, and thermoelectric sensors Temperature sensors, infrared sensors, humidity sensors Optical, electro-optical and fibre-optic sensors and systems, photonic sensors Biosensors, wearable and implantable sensors and systems, immunosensors Gas and chemical sensors and systems, polymer sensors Acoustic and ultrasonic sensors Haptic sensors and devices Smart and intelligent sensors and systems Nanosensors, NEMS, MEMS, and BioMEMS Quantum sensors Sensor systems: sensor data fusion, signals, processing and interfacing, signal conditioning.