{"title":"Clinical risk factors analysis and prevention of osteoporosis as a complication of diabetes","authors":"","doi":"10.1007/s13410-023-01303-3","DOIUrl":null,"url":null,"abstract":"<h3>Abstract</h3> <span> <h3>Objective</h3> <p>Osteoporosis is a common complication of type 2 diabetes. This study aimed to provide a basis for the clinical prevention and treatment of osteoporosis as a complication of type 2 diabetes.</p> </span> <span> <h3>Methods</h3> <p>We retrospectively analyzed patients hospitalized with type 2 diabetes with or without osteoporosis. Binary logistic regression was performed to assess the relationship between the assessed indexes and the risk of type 2 diabetes with osteoporosis. Receiver operating characteristic curves were created to evaluate the efficacy of these indexes in predicting osteoporosis in patients with type 2 diabetes.</p> </span> <span> <h3>Results</h3> <p>The cohort comprised 1,811 patients with type 2 diabetes and 1,758 with type 2 diabetes combined with osteoporosis. The basic indexes (height and weight) and glucose metabolism indexes (glycated hemoglobin A (HbA1c) and fasting plasma glucose/fasting blood glucose) were positively correlated with the bone metabolism indexes. Receiver operating characteristic curve analysis showed that HbA1c was an effective predictor of osteoporosis risk, with an area under the curve of 70.1%. When the HbA1c of patients with type 2 diabetes was between 6% and 6.45% or reached 6.45% at a long-term stable state, the risk of osteoporosis was increased. The risk of osteoporosis was also increased in patients with type 2 diabetes who were older than 59.5 years.</p> </span> <span> <h3>Conclusion</h3> <p>HbA1c and fasting plasma glucose/fasting blood glucose were significantly correlated with bone metabolism in patients with type 2 diabetes with and without osteoporosis. Clinical monitoring of the HbA1c may be useful in preventing osteoporosis in patients with type 2 diabetes.</p> </span>","PeriodicalId":50328,"journal":{"name":"International Journal of Diabetes in Developing Countries","volume":null,"pages":null},"PeriodicalIF":0.7000,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Diabetes in Developing Countries","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s13410-023-01303-3","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
引用次数: 0
Abstract
Objective
Osteoporosis is a common complication of type 2 diabetes. This study aimed to provide a basis for the clinical prevention and treatment of osteoporosis as a complication of type 2 diabetes.
Methods
We retrospectively analyzed patients hospitalized with type 2 diabetes with or without osteoporosis. Binary logistic regression was performed to assess the relationship between the assessed indexes and the risk of type 2 diabetes with osteoporosis. Receiver operating characteristic curves were created to evaluate the efficacy of these indexes in predicting osteoporosis in patients with type 2 diabetes.
Results
The cohort comprised 1,811 patients with type 2 diabetes and 1,758 with type 2 diabetes combined with osteoporosis. The basic indexes (height and weight) and glucose metabolism indexes (glycated hemoglobin A (HbA1c) and fasting plasma glucose/fasting blood glucose) were positively correlated with the bone metabolism indexes. Receiver operating characteristic curve analysis showed that HbA1c was an effective predictor of osteoporosis risk, with an area under the curve of 70.1%. When the HbA1c of patients with type 2 diabetes was between 6% and 6.45% or reached 6.45% at a long-term stable state, the risk of osteoporosis was increased. The risk of osteoporosis was also increased in patients with type 2 diabetes who were older than 59.5 years.
Conclusion
HbA1c and fasting plasma glucose/fasting blood glucose were significantly correlated with bone metabolism in patients with type 2 diabetes with and without osteoporosis. Clinical monitoring of the HbA1c may be useful in preventing osteoporosis in patients with type 2 diabetes.
期刊介绍：
International Journal of Diabetes in Developing Countries is the official journal of Research Society for the Study of Diabetes in India. This is a peer reviewed journal and targets a readership consisting of clinicians, research workers, paramedical personnel, nutritionists and health care personnel working in the field of diabetes. Original research articles focusing on clinical and patient care issues including newer therapies and technologies as well as basic science issues in this field are considered for publication in the journal. Systematic reviews of interest to the above group of readers are also accepted.
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