Contrast-Free High Frame Rate Ultrasound Imaging for Assessment of Vascular Remodeling During Wound Healing

IF 5.6 4区 医学 Q1 ENGINEERING, BIOMEDICAL
Irbm Pub Date : 2023-12-27 DOI:10.1016/j.irbm.2023.100818
David Lemonnier , Ikram Mezghani , Georgios Theocharidis , Brandon J. Sumpio , Samuel K. Sia , Aristidis Veves , Parag V. Chitnis
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Abstract

Background

Monitoring of wound healing progression is critical due to the risk of infection, non-healing wounds, or evolution towards a chronic state. Tissue vasculature is one of the most representative features reflecting healing status. This study explores the feasibility of vascular ultrasound imaging of open wounds and the extraction of vascular-related features in a longitudinal study.

Material and methods

C57BL/6 mice received a 1 cm-diameter full-thickness wound on their dorsum and were imaged using ultrasound from the surgical day (Day 0) to 25 days post-wounding. The high frame rate, plane waves acquisitions with a 15 MHz transducer were postprocessed with Singular Value Decomposition (SVD) filtering to provide vascular information.

Results

Vascularity Index (VI) calculations showed an increased vascular signal in the wound from Day 2 post-wounding and were significantly higher from day 6 to day 10 post-wounding compared to Day 0 (p<0.05). VI values were back to the basal level after 3 weeks. In comparison, no significant difference was highlighted for the vascular signal in the peri-wound area.

Conclusions

These results show that vascular ultrasound imaging can be applied to track vascular changes of open wounds during the healing process. This approach may also be extended to other types of wounds for detecting early signs likely to cause complications.

Abstract Image

Abstract Image

用于评估伤口愈合过程中血管重塑的无对比高帧率超声波成像技术
背景由于存在感染、伤口不愈合或向慢性状态发展的风险,因此监测伤口愈合进展至关重要。组织血管是反映愈合状态的最具代表性的特征之一。本研究探讨了开放性伤口血管超声成像的可行性,以及在纵向研究中提取血管相关特征的可行性。材料与方法C57BL/6小鼠背侧有一个直径1厘米的全厚伤口,从手术当天(第0天)到伤口愈合后25天,小鼠都接受了超声成像。结果血管指数(VI)计算显示,自伤口愈合后第 2 天起,伤口内的血管信号增加,伤口愈合后第 6 天至第 10 天的血管信号明显高于第 0 天(p<0.05)。3 周后,VI 值恢复到基本水平。结论:这些结果表明,血管超声成像可用于跟踪愈合过程中开放性伤口的血管变化。这一方法也可应用于其他类型的伤口,以检测可能导致并发症的早期征兆。
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来源期刊
Irbm
Irbm ENGINEERING, BIOMEDICAL-
CiteScore
10.30
自引率
4.20%
发文量
81
审稿时长
57 days
期刊介绍: IRBM is the journal of the AGBM (Alliance for engineering in Biology an Medicine / Alliance pour le génie biologique et médical) and the SFGBM (BioMedical Engineering French Society / Société française de génie biologique médical) and the AFIB (French Association of Biomedical Engineers / Association française des ingénieurs biomédicaux). As a vehicle of information and knowledge in the field of biomedical technologies, IRBM is devoted to fundamental as well as clinical research. Biomedical engineering and use of new technologies are the cornerstones of IRBM, providing authors and users with the latest information. Its six issues per year propose reviews (state-of-the-art and current knowledge), original articles directed at fundamental research and articles focusing on biomedical engineering. All articles are submitted to peer reviewers acting as guarantors for IRBM''s scientific and medical content. The field covered by IRBM includes all the discipline of Biomedical engineering. Thereby, the type of papers published include those that cover the technological and methodological development in: -Physiological and Biological Signal processing (EEG, MEG, ECG…)- Medical Image processing- Biomechanics- Biomaterials- Medical Physics- Biophysics- Physiological and Biological Sensors- Information technologies in healthcare- Disability research- Computational physiology- …
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