[The role of apolipoprotein C3 in the regulation of nonalcoholic fatty liver disease, glucose and lipid metabolism, and islet β cell function].

Q3 Medicine
生理学报 Pub Date : 2023-12-25
Shan Yan, Zhi-Yong Ding, Yuan Gao, Wang-Jia Mao, Xiao-Yun Cheng
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引用次数: 0

Abstract

As a member of the apolipoprotein C (ApoC) family with a relatively high content, ApoC3 plays a major role in the regulation of triglyceride metabolism, and plays an important role in the occurrence and development of cardiovascular diseases, glucose and lipid metabolism disorders. Nonalcoholic fatty liver disease (NAFLD) refers to the accumulation of a large amount of fat in the liver in the absence of a history of chronic alcohol consumption or other damage to the liver. A large number of previous studies have shown that there is a correlation between the gene polymorphism and high expression of ApoC3 and NAFLD. In the context of hypertriglyceridemia (HTG), this article reviews the relationship between ApoC3 and NAFLD, glucose and lipid metabolism, and islet β cell function, showing that ApoC3 can not only inhibit lipoprotein lipase (LPL) and hepatic lipase (HL) activity, delay the decomposition of triglyceride in plasma to maintain the body's energy metabolism during fasting, but also be significantly increased under insulin resistance, prompting the liver to secrete a large amount of very low-density lipoprotein (VLDL) to induce HTG. Therefore, targeting and inhibiting ApoC3 might become a new approach to treat HTG. Increasing evidence suggests that ApoC3 does not appear to be an independent "contributor" to NAFLD. Similarly, our previous studies have shown that ApoC3 is not an independent factor triggering islet β cell dysfunction in ApoC3 transgenic mice, but in a state of excess nutrition, HTG triggered by ApoC3 high expression may exacerbate the effects of hyperglycemia and insulin resistance on islet β cell function, and the underlying mechanism remains to be further discussed.

[脂蛋白 C3 在调节非酒精性脂肪肝、葡萄糖和脂质代谢以及胰岛 β 细胞功能中的作用]。
载脂蛋白C3作为载脂蛋白C(ApoC)家族中含量相对较高的成员,在甘油三酯代谢调节中发挥着重要作用,在心血管疾病、糖和脂代谢紊乱的发生和发展中扮演着重要角色。非酒精性脂肪肝(NAFLD)是指在没有长期饮酒史或其他肝脏损伤史的情况下,肝脏中堆积大量脂肪。以往的大量研究表明,载脂蛋白 C3 的基因多态性和高表达与非酒精性脂肪肝之间存在相关性。本文结合高甘油三酯血症(HTG),综述了载脂蛋白C3与非酒精性脂肪肝、糖脂代谢、胰岛β细胞功能之间的关系,表明载脂蛋白C3不仅能抑制脂蛋白脂肪酶(LPL)和肝脂肪酶(HL)的活性、还能在胰岛素抵抗的情况下显著增加,促使肝脏分泌大量极低密度脂蛋白(VLDL),诱发高血脂症。因此,靶向抑制载脂蛋白C3可能成为治疗高血脂症的一种新方法。越来越多的证据表明,载脂蛋白C3似乎并不是非酒精性脂肪肝的独立 "诱因"。同样,我们之前的研究也表明,载脂蛋白C3并不是引发载脂蛋白C3转基因小鼠胰岛β细胞功能障碍的独立因素,但在营养过剩的状态下,载脂蛋白C3高表达引发的高胰岛素血症可能会加剧高血糖和胰岛素抵抗对胰岛β细胞功能的影响,其潜在机制仍有待进一步探讨。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
生理学报
生理学报 Medicine-Medicine (all)
CiteScore
1.20
自引率
0.00%
发文量
4820
期刊介绍: Acta Physiologica Sinica (APS) is sponsored by the Chinese Association for Physiological Sciences and Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences (CAS), and is published bimonthly by the Science Press, China. APS publishes original research articles in the field of physiology as well as research contributions from other biomedical disciplines and proceedings of conferences and symposia of physiological sciences. Besides “Original Research Articles”, the journal also provides columns as “Brief Review”, “Rapid Communication”, “Experimental Technique”, and “Letter to the Editor”. Articles are published in either Chinese or English according to authors’ submission.
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