[Exercise promotes healthy cardiovascular aging].

Q3 Medicine

生理学报 Pub Date : 2023-12-25

Min Li, Meng-Ya Feng, Zi-Hang Feng, Jia Li, Xing Zhang, Feng Gao

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引用次数: 0

Abstract

Cardiovascular disease (CVD) is an important factor threatening the health of the elderly. Aging leads to changes in the structure and function of the cardiovascular system, which increases the risk of CVD in the elderly. Cardiac aging is characterized by increased left ventricular wall thickness, increased degree of myocardial fibrosis, increased cardiac hardness, and decreased cardiac function, while vascular aging is characterized by enlarged lumen, thickened wall, and endothelial dysfunction. Promoting healthy cardiovascular aging means reducing the age-related cardiovascular dysfunction and the risks of CVD. Exercise is a crucial means for the treatment and rehabilitation of CVD. Exercise reduces the risk factors of CVD, remodels the cardiovascular structure, and increases the resistance of heart to detrimental stimulus, which promotes healthy cardiovascular aging. The improved mitochondrial function via exercise plays a key role in the health effects of exercise. In addition, exercise promotes the secretion of exerkines in various tissues and organs, which plays a role in reducing inflammation, improving metabolism, inhibiting apoptosis, etc., thus benefiting cardiovascular health. This review discusses the mechanism and potential application of exercise in promoting healthy cardiovascular aging. Exploring the specific mechanisms underlying exercise-induced cardiovascular health and formulating accurate exercise prescriptions for different populations is an important direction to promote healthy cardiovascular aging and prevent CVD.

本刊更多论文

[运动促进心血管健康老化]。

心血管疾病（CVD）是威胁老年人健康的一个重要因素。衰老会导致心血管系统的结构和功能发生变化，从而增加老年人患心血管疾病的风险。心脏衰老的特征是左心室壁厚度增加、心肌纤维化程度增加、心脏硬度增加和心功能下降，而血管衰老的特征是管腔扩大、管壁增厚和内皮功能障碍。促进心血管健康老化意味着减少与年龄相关的心血管功能障碍和心血管疾病的风险。运动是治疗和康复心血管疾病的重要手段。运动能减少心血管疾病的危险因素，重塑心血管结构，增强心脏对有害刺激的抵抗力，从而促进心血管健康老化。通过运动改善线粒体功能在运动的健康效应中起着关键作用。此外，运动还能促进各组织器官分泌外泌钾素，起到减轻炎症、改善新陈代谢、抑制细胞凋亡等作用，从而有益于心血管健康。本综述探讨了运动促进心血管健康老化的机制和潜在应用。探索运动诱导心血管健康的具体机制，并针对不同人群制定准确的运动处方，是促进心血管健康老龄化和预防心血管疾病的重要方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

生理学报 Medicine-Medicine (all)

CiteScore

1.20

自引率

0.00%

发文量

4820

期刊介绍： Acta Physiologica Sinica (APS) is sponsored by the Chinese Association for Physiological Sciences and Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences (CAS), and is published bimonthly by the Science Press, China. APS publishes original research articles in the field of physiology as well as research contributions from other biomedical disciplines and proceedings of conferences and symposia of physiological sciences. Besides “Original Research Articles”, the journal also provides columns as “Brief Review”, “Rapid Communication”, “Experimental Technique”, and “Letter to the Editor”. Articles are published in either Chinese or English according to authors’ submission.