Lower creatinine to cystatin C ratio is associated with an increased risk of MASLD: A cross-sectional and prospective study of 368,634 UK Biobank participants

IF 3 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Clinical Endocrinology Pub Date : 2023-12-26 DOI:10.1111/cen.14990

Jiaren Wang, Lin Zeng, Chang Hong, Hao Cui, Weizhen Wang, Hongbo Zhu, Qimei Li, Yan Li, Ruining Li, Jingzhe He, Hong Zhu, Li Liu, Lushan Xiao

{"title":"Lower creatinine to cystatin C ratio is associated with an increased risk of MASLD: A cross-sectional and prospective study of 368,634 UK Biobank participants","authors":"Jiaren Wang, Lin Zeng, Chang Hong, Hao Cui, Weizhen Wang, Hongbo Zhu, Qimei Li, Yan Li, Ruining Li, Jingzhe He, Hong Zhu, Li Liu, Lushan Xiao","doi":"10.1111/cen.14990","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Objective</h3>\n \n <p>Metabolic dysfunction-associated steatotic liver disease (MASLD) affects many populations, and screening out the high-risk populations at an early stage is a challenge. As a sarcopenia index, the relationship between creatinine to cystatin C ratio (CCR) and MASLD remains unclear. This cross-sectional, prospective study aimed to explore the relationship between CCR and MASLD. Design Firstly, explored the correlation between CCR and MASLD in cross-sectional analyses. Then excluded the population with baseeline diagnosis of MASLD and analyzed the association with baseline CCR levels and the onset of MASLD in the population with available follow-up data. Univariate and multivariate logistic regression analyses were used to calculate odds ratios (ORs) to evaluate the association between CCR levels and MASLD.</p>\n </section>\n \n <section>\n \n <h3> Patients and Measurements</h3>\n \n <p>This study included 368,634 participants from the UK Biobank for cross-sectional and prospective analyses. The demographic characteristics and laboratory measurements of all participants were obtained from the UK Biobank. MASLD was diagnosed according to the multi-society consensus nomenclature. Hepatic steatosis was defined as FLI  ≥60.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>We grouped the study participants according to CCR tertiles. In cross-sectional analyses, participants in CCR tertile 1 had the highest MASLD risk (OR: 1.070, 95% CI: 1.053−1.088, <i>p</i> < .001). And the similar association was observed in the prospective analyses (CCR tertile 1 OR: 1.340, 95% CI: 1.077−1.660, <i>p</i> = .009; CCR tertile 2 OR: 1.217, 95% CI: 1.021−1.450, <i>p</i> = .029, respectively). After stratification by gender, the significant association between CCR and the onset of MASLD was only observed in males (CCR tertile 1 OR: 1.639, 95% CI: 1.160−2.317, <i>p</i> = .005; CCR tertile 2 OR: 1.322, 95% CI: 1.073−1.628, <i>p</i> = .005, respectively).</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>Our results indicated that lower CCR was significantly associated with higher risk of MASLD, based on which predictive models can be developed to screen populations at high risk of developing MASLD.</p>\n </section>\n </div>","PeriodicalId":10346,"journal":{"name":"Clinical Endocrinology","volume":null,"pages":null},"PeriodicalIF":3.0000,"publicationDate":"2023-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Endocrinology","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/cen.14990","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}

引用次数: 0

Abstract

Objective

Metabolic dysfunction-associated steatotic liver disease (MASLD) affects many populations, and screening out the high-risk populations at an early stage is a challenge. As a sarcopenia index, the relationship between creatinine to cystatin C ratio (CCR) and MASLD remains unclear. This cross-sectional, prospective study aimed to explore the relationship between CCR and MASLD. Design Firstly, explored the correlation between CCR and MASLD in cross-sectional analyses. Then excluded the population with baseeline diagnosis of MASLD and analyzed the association with baseline CCR levels and the onset of MASLD in the population with available follow-up data. Univariate and multivariate logistic regression analyses were used to calculate odds ratios (ORs) to evaluate the association between CCR levels and MASLD.

Patients and Measurements

This study included 368,634 participants from the UK Biobank for cross-sectional and prospective analyses. The demographic characteristics and laboratory measurements of all participants were obtained from the UK Biobank. MASLD was diagnosed according to the multi-society consensus nomenclature. Hepatic steatosis was defined as FLI  ≥60.

Results

We grouped the study participants according to CCR tertiles. In cross-sectional analyses, participants in CCR tertile 1 had the highest MASLD risk (OR: 1.070, 95% CI: 1.053−1.088, p < .001). And the similar association was observed in the prospective analyses (CCR tertile 1 OR: 1.340, 95% CI: 1.077−1.660, p = .009; CCR tertile 2 OR: 1.217, 95% CI: 1.021−1.450, p = .029, respectively). After stratification by gender, the significant association between CCR and the onset of MASLD was only observed in males (CCR tertile 1 OR: 1.639, 95% CI: 1.160−2.317, p = .005; CCR tertile 2 OR: 1.322, 95% CI: 1.073−1.628, p = .005, respectively).

Conclusion

Our results indicated that lower CCR was significantly associated with higher risk of MASLD, based on which predictive models can be developed to screen populations at high risk of developing MASLD.

查看原文本刊更多论文

肌酐与胱抑素 C 比率较低与 MASLD 风险增加有关：对 368,634 名英国生物库参与者进行的横断面前瞻性研究。

目的：代谢功能障碍相关性脂肪性肝病（MASLD）影响着许多人群，而早期筛查出高风险人群是一项挑战。作为一项肌肉疏松指数，肌酐与胱抑素 C 比值（CCR）与 MASLD 之间的关系仍不明确。本横断面前瞻性研究旨在探讨肌酸酐与胱抑素 C 比值与肌肉萎缩症之间的关系。设计首先，在横断面分析中探讨肌酐与胱抑素C比值与MASLD之间的相关性。然后排除基线诊断为MASLD的人群，在有随访数据的人群中分析基线CCR水平与MASLD发病的相关性。采用单变量和多变量逻辑回归分析计算几率比（ORs），以评估CCR水平与MASLD之间的关系：该研究纳入了英国生物库中的 368,634 名参与者，进行横断面和前瞻性分析。所有参与者的人口统计学特征和实验室测量结果均来自英国生物库。MASLD根据多协会共识命名法进行诊断。肝脏脂肪变性定义为FLI≥60：我们根据 CCR tertiles 对研究参与者进行了分组。在横断面分析中，CCR 三分层 1 的参与者具有最高的 MASLD 风险（OR：1.070，95% CI：1.053-1.088，P 结论：CCR 三分层 1 的参与者具有最高的 MASLD 风险（OR：1.070，95% CI：1.053-1.088，P 结论）：我们的研究结果表明，较低的 CCR 与较高的 MASLD 风险显著相关，可据此建立预测模型来筛查 MASLD 高风险人群。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Clinical Endocrinology 医学-内分泌学与代谢

CiteScore

6.40

自引率

3.10%

发文量

192

审稿时长

1 months

期刊介绍： Clinical Endocrinology publishes papers and reviews which focus on the clinical aspects of endocrinology, including the clinical application of molecular endocrinology. It does not publish papers relating directly to diabetes care and clinical management. It features reviews, original papers, commentaries, correspondence and Clinical Questions. Clinical Endocrinology is essential reading not only for those engaged in endocrinological research but also for those involved primarily in clinical practice.