Genotyping of Whipple's disease presenting as sclerosing mesenteritis: A case report.

IF 1.7 Q3 INFECTIOUS DISEASES

GERMS Pub Date : 2023-06-30 eCollection Date: 2023-06-01 DOI:10.18683/germs.2023.1383

Areti Kalfoutzou, Sofia Makka, Theodora Stivarou, Myrto Koutantou, Panagiota Kelidi, Maria Papanikolaou, Nikolaos Chaleplidis, Christos Tekedis, Eleni Mostratou, Emmanouil Angelakis, Panagiotis Petrikkos

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Abstract

Introduction: There are very few reported cases of Whipple disease (WD), a rare chronic disease in Greece. In this report, we present a classic WD case in a Greek firefighter and the detection of an autochthonous Tropheryma whipplei genotype in this Greek autochthonous citizen.

Case report: We describe a patient with chronic diarrhea and arthritis who was misdiagnosed with sclerosing mesenteritis three years previously and was unsuccessfully treated with corticosteroids. After the effectuation of histopathologic examination and PCR against T. whipplei, he was diagnosed with classic WD. Moreover, for the first time in Greece, we proceeded with T. whipplei genotyping targeting four highly variable genomic sequences and we concluded that the patient was infected by T. whipplei genotype 120.

Conclusions: We highlight the necessity to explore T. whipplei presence and its genotypes through the Greek population and to identify if genotype 120 is the predominant strain in the Hellenic territory.

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对表现为硬化性肠系膜炎的惠普尔病进行基因分型：病例报告

导言：惠普尔病（WD）在希腊是一种罕见的慢性疾病，目前报道的病例很少。在本报告中，我们介绍了一名希腊消防员的典型 WD 病例，并在这名希腊本土公民中检测到了自体 Tropheryma whipplei 基因型：我们描述了一名患有慢性腹泻和关节炎的患者，三年前他被误诊为硬化性肠系膜炎，接受皮质类固醇治疗未果。经过组织病理学检查和针对白喉杆菌的 PCR 检测，他被确诊为典型的 WD。此外，我们还在希腊首次针对四个高度可变的基因组序列进行了T.whipplei基因分型，并得出结论：该患者感染的是T.whipplei基因型120：结论：我们强调有必要在希腊人口中调查白喉杆菌的存在及其基因型，并确定基因型 120 是否是希腊境内的主要菌株。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

GERMS INFECTIOUS DISEASES-

CiteScore

2.80

自引率

5.00%

发文量