A case report and literature review of iatrogenic copper deficiency myeloneuropathy due to zinc treatment in patients with Wilson’s disease

IF 0.4 Q3 MEDICINE, GENERAL & INTERNAL
C. Pawa, Kexin Ang, Y. R. Chiew
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引用次数: 0

Abstract

Iatrogenic copper deficiency is rare in patients with Wilson’s disease. We present a case of iatrogenic copper deficiency myeloneuropathy secondary to zinc treatment for Wilson’s disease and compare the patient’s clinical features with existing cases. Our study highlights the importance of recognizing subtle clinical manifestations and counselling patients receiving copper-reducing treatment to watch for symptoms of myeloneuropathy. Early biochemical testing, including serum copper, caeruloplasmin and zinc levels, as well as magnetic resonance imaging of the spine and electrophysiological studies, may be helpful in diagnosing copper deficiency-related myeloneuropathy due to zinc treatment. Early detection and treatment of copper deficiency may lead to good recovery of neurological symptoms.
威尔逊氏病患者因锌治疗引起的先天性铜缺乏性骨髓神经病的病例报告和文献综述
先天性铜缺乏症在威尔逊氏病患者中非常罕见。我们介绍了一例因锌治疗威尔森氏病而继发的先天性铜缺乏性骨髓神经病,并将该患者的临床特征与现有病例进行了比较。我们的研究强调了识别细微临床表现的重要性,并建议接受降铜治疗的患者注意骨髓神经病的症状。早期生化检测(包括血清铜、脑磷脂和锌水平)以及脊柱磁共振成像和电生理学研究,可能有助于诊断锌治疗引起的铜缺乏相关性骨髓神经病。早期发现和治疗铜缺乏症可使神经症状得到良好恢复。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Proceedings of Singapore Healthcare
Proceedings of Singapore Healthcare MEDICINE, GENERAL & INTERNAL-
CiteScore
0.90
自引率
0.00%
发文量
42
审稿时长
15 weeks
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