Response to aerobic training reveals key differences in cardiovascular adaptation in an adenine diet induced model of chronic kidney disease

Abstract

Background: Rat models generated by selective breeding for low (LRT) or high (HRT) response to aerobic training closely embody human phenotypes and can be used to understand the exercise-disease linkages. Aerobic endurance training has been proposed as a model of exercise intervention capable of improving or minimizing the negative consequences of chronic diseases including chronic kidney disease (CKD). Objectives: We hypothesized that resistance to aerobic training induces kidney damage in CKD settings. Methods: Male and Female LRT and HRT rats (~ 17 months of age; n = 30) were freely fed with rodent chow supplemented with