Investigating the blood rheology in the first trimester pregnancies with high risk for preeclampsia

IF 2.1 4区医学 Q3 HEMATOLOGY

Clinical hemorheology and microcirculation Pub Date : 2023-12-18 DOI:10.3233/ch-232026

Lütfiye Uygur, Merve Kabasakal Ilter, Nazlı Helvacı, Muhammed Edib Mokresh, Muhammed Kahya, Emir Muvaffak, Muhammet Huzeyfe Elmuhammed, I. Ayhan, Pınar Kumru

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引用次数: 0

Abstract

BACKGROUND: Pregnancy is a dynamic process associated with changes in vascular and rheological resistance. Maternal maladaptation to these changes is the leading cause of pregnancy complications such as preeclampsia. OBJECTIVE: This study aimed to assess the hemorheological alterations in pregnancies with a high risk for preeclampsia in the first trimester. METHODS: Ninety-two pregnant women were allocated into the high preeclampsia risk group (37 cases) and control groups (55 cases). Plasma and whole blood viscosity and red blood cell morphodynamic properties, including deformability and aggregation were assessed by Brookfield viscometer and laser-assisted optical rotational cell analyzer (LORRCA) at 11–14 gestational weeks. RESULTS: Whole blood viscosity was significantly higher in the high-risk group at all shear rates. Plasma viscosity and hematologic factors showed no differences between the groups. Hematocrit levels positively correlated with high blood viscosity only in the high-risk group. There were no significant changes in the other deformability and aggregation parameters. CONCLUSIONS: Changes in the whole blood viscosity of pregnant women with high preeclampsia risk refer to impaired microcirculation beginning from the early weeks of gestation. We suggest that the whole blood viscosity is consistent with the preeclampsia risk assessment in the first trimester, and its measurement might be promising for identifying high-preeclampsia-risk pregnancies.

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调查子痫前期高危妊娠头三个月的血液流变学情况

背景：妊娠是一个动态过程，与血管和流变阻力的变化有关。母体对这些变化的不适应是导致子痫前期等妊娠并发症的主要原因。目的：本研究旨在评估妊娠头三个月子痫前期高危孕妇的血液流变学变化。方法：92 名孕妇被分为子痫前期高风险组（37 例）和对照组（55 例）。在 11-14 孕周时，用 Brookfield 粘度计和激光辅助光学旋转细胞分析仪（LORRCA）评估血浆和全血粘度以及红细胞形态动力学特性，包括变形性和聚集性。结果：在所有剪切率下，高风险组的全血粘度都明显较高。血浆粘度和血液学因素在各组间无差异。只有高风险组的血细胞比容水平与高血液粘度呈正相关。其他变形和聚集参数没有明显变化。结论：子痫前期高危孕妇全血粘度的变化表明，微循环从妊娠早期就开始受损。我们认为，全血粘度与妊娠头三个月的子痫前期风险评估是一致的，测量全血粘度可能有助于识别子痫前期高危孕妇。

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来源期刊

Clinical hemorheology and microcirculation 医学-外周血管病

CiteScore

4.30

自引率

33.30%

发文量

170

期刊介绍： Clinical Hemorheology and Microcirculation, a peer-reviewed international scientific journal, serves as an aid to understanding the flow properties of blood and the relationship to normal and abnormal physiology. The rapidly expanding science of hemorheology concerns blood, its components and the blood vessels with which blood interacts. It includes perihemorheology, i.e., the rheology of fluid and structures in the perivascular and interstitial spaces as well as the lymphatic system. The clinical aspects include pathogenesis, symptomatology and diagnostic methods, and the fields of prophylaxis and therapy in all branches of medicine and surgery, pharmacology and drug research. The endeavour of the Editors-in-Chief and publishers of Clinical Hemorheology and Microcirculation is to bring together contributions from those working in various fields related to blood flow all over the world. The editors of Clinical Hemorheology and Microcirculation are from those countries in Europe, Asia, Australia and America where appreciable work in clinical hemorheology and microcirculation is being carried out. Each editor takes responsibility to decide on the acceptance of a manuscript. He is required to have the manuscript appraised by two referees and may be one of them himself. The executive editorial office, to which the manuscripts have been submitted, is responsible for rapid handling of the reviewing process. Clinical Hemorheology and Microcirculation accepts original papers, brief communications, mini-reports and letters to the Editors-in-Chief. Review articles, providing general views and new insights into related subjects, are regularly invited by the Editors-in-Chief. Proceedings of international and national conferences on clinical hemorheology (in original form or as abstracts) complete the range of editorial features.