Regulation of litter size in sheep (Ovis aries) by the GDF9 and BMP15 genes

IF 3.5 2区农林科学 Q1 AGRICULTURE, MULTIDISCIPLINARY

Annals of Agricultural Science Pub Date : 2023-12-01 DOI:10.1016/j.aoas.2023.12.004

Yang Chen , Xuesong Shan , Huaizhi Jiang , Limin Sun , Zhenhua Guo

引用次数: 0

Abstract

The mutation types GDF9 S395F and S427R increase the ovulation rate in heterozygotes, while the homozygous form leads to infertility. This study presents a meta-analysis of GDF9 and BMP15 SNPs related to sheep litter size (LS). The results showed that simulation of the molecular recognition of GDF9 R453H, S395F, and S427R was performed to study the effect on the GDF9 dimer. S395F and S427R dimer binding ability of mutant heterozygotes was improved, thereby improving LS. The binding ability of mutant homozygous dimers was reduced, resulting in infertility. The results of this study will provide important references for animal breeding.

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GDF9 和 BMP15 基因对绵羊（Ovis aries）窝产仔数的调控

GDF9 S395F和S427R突变类型可提高杂合子的排卵率，而同合子则会导致不育。本研究对与绵羊产仔数（LS）相关的GDF9和BMP15 SNPs进行了荟萃分析。结果显示，模拟了 GDF9 R453H、S395F 和 S427R 的分子识别，研究了它们对 GDF9 二聚体的影响。突变杂合子的S395F和S427R二聚体结合能力得到改善，从而提高了LS。突变型同源二聚体的结合能力降低，导致不育。该研究结果将为动物育种提供重要参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Agricultural Science AGRICULTURE, MULTIDISCIPLINARY-

CiteScore

12.60

自引率

0.00%

发文量

审稿时长

33 days

期刊介绍： Annals of Agricultural Sciences (AOAS) is the official journal of Faculty of Agriculture, Ain Shams University. AOAS is an open access peer-reviewed journal publishing original research articles and review articles on experimental and modelling research at laboratory, field, farm, landscape, and industrial levels. AOAS aims to maximize the quality of the agricultural sector across the globe with emphasis on the Arabian countries by focusing on publishing the high-quality applicable researches, in addition to the new methods and frontiers leading to maximizing the quality and quantity of both plant and animal yield and final products.