Role of Phytochemicals against Diabetic Nephropathy: An Insight into Molecular Receptors

Q4 Pharmacology, Toxicology and Pharmaceutics

Toxicology International Pub Date : 2023-12-11 DOI:10.18311/ti/2023/v30i4/30998

V. S. Devi, Chitra Vellapandian, R. Ilavarasan, M. Sumithra

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Abstract

Diabetic nephropathy is a growing disorder among diabetic patients. A multifactorial disorder affects various factors like elevated metabolism and hypertension and blocks various molecular pathways such as AGE (Advanced Glycation End Product), RAAS (Renin Angiotensin Aldosterone System), PKC (Protein Kinase C), Hexosomamine, and polyol. Individuals are temporarily relieved by available combined treatments like ACE inhibitors and calcium channel blockers for blood pressure control as well as for severe albuminuria conditions, but these therapies have significant adverse health consequences. Herbal preparations play a potential role in the cure of various ailments that come first in the mind for humans which have least or without side effects and are economically stable for consumption. Since these constituents are cost-effective and have minimal side effects, scientifically validated phytochemicals or combined formulations are significant against diabetic nephropathy. This review focuses on the mechanism of receptors and the genes involved in the disease and the potential phytochemicals effectiveness against it.

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植物化学物质对糖尿病肾病的作用：洞察分子受体

糖尿病肾病是糖尿病患者中一种日益严重的疾病。糖尿病肾病是一种多因素疾病，影响新陈代谢升高和高血压等多种因素，并阻断 AGE（高级糖化终产物）、RAAS（肾素血管紧张素醛固酮系统）、PKC（蛋白激酶 C）、六胺和多元醇等多种分子通路。现有的联合疗法，如 ACE 抑制剂和钙通道阻滞剂，可暂时缓解血压控制和严重白蛋白尿的症状，但这些疗法会对健康产生重大不利影响。草药制剂在治疗人类首先想到的各种疾病方面发挥着潜在的作用，它们的副作用最小或没有副作用，而且食用起来经济稳定。由于这些成分具有成本效益且副作用极小，因此经过科学验证的植物化学物质或组合配方对糖尿病肾病具有重要的防治作用。这篇综述的重点是糖尿病肾病的受体机制和相关基因，以及潜在的植物化学物质对糖尿病肾病的疗效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Toxicology International Environmental Science-Health, Toxicology and Mutagenesis

CiteScore

0.60

自引率

0.00%

发文量

期刊介绍： Toxicology International is a peer-reviewed International Research Journal published bi-annually by the Society of Toxicology, India. The Journal is concerned with various disciplines of Toxicology including man, animals, plants and environment and publishes research, review and general articles besides opinions, comments, news-highlights and letters to editor.