Diabetes mellitus and prostate cancer risk: A mendelian randomization analysis

IF 4.2 3区医学 Q1 ENDOCRINOLOGY & METABOLISM

World Journal of Diabetes Pub Date : 2023-12-15 DOI:10.4239/wjd.v14.i12.1839

Jian-Xu Yuan, Qing Jiang, Sheng-Jie Yu

引用次数: 0

Abstract

BACKGROUND Some studies have directed towards an association between diabetes mellitus (DM) and prostate cancer (PCa); however, this specific relationship remains inconclusive. In recent years, Mendelian randomization (MR) has become a widely used analytical method for inferring epidemiological causes. AIM To investigated the potential relationship between DM and PCa using MR. METHODS We downloaded relevant data on "diabetes" and "PCa" from the IEU OpenGWAS project database, performed three different methods to conduct MR, and carried out sensitivity analysis for verification. RESULTS The results indicated that DM was an independent risk factor for PCa. The odds ratio (OR) values obtained using the inverse variance weighted method in this study were as follows: OR = 1.018 (95% confidence interval: 1.004-1.032), P = 0.014. CONCLUSION We found that DM could increase the incidence rate of PCa.

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糖尿病与前列腺癌风险：孟德尔随机分析

背景一些研究表明，糖尿病（DM）与前列腺癌（PCa）之间存在关联；然而，这种具体关系仍未确定。近年来，孟德尔随机化（Mendelian randomization，MR）已成为推断流行病学原因的一种广泛使用的分析方法。目的利用孟德尔随机分析法研究 DM 与 PCa 之间的潜在关系。方法我们从 IEU OpenGWAS 项目数据库中下载了 "糖尿病 "和 "PCa "的相关数据，采用三种不同的方法进行 MR 分析，并进行敏感性分析进行验证。结果结果表明，糖尿病是 PCa 的独立风险因素。本研究采用反方差加权法得出的几率比（OR）值如下：OR = 1.018（95% 置信区间：1.004-1.032），P = 0.014。结论我们发现 DM 会增加 PCa 的发病率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

World Journal of Diabetes ENDOCRINOLOGY & METABOLISM-

自引率

2.40%

发文量

909

期刊介绍： The WJD is a high-quality, peer reviewed, open-access journal. The primary task of WJD is to rapidly publish high-quality original articles, reviews, editorials, and case reports in the field of diabetes. In order to promote productive academic communication, the peer review process for the WJD is transparent; to this end, all published manuscripts are accompanied by the anonymized reviewers’ comments as well as the authors’ responses. The primary aims of the WJD are to improve diagnostic, therapeutic and preventive modalities and the skills of clinicians and to guide clinical practice in diabetes. Scope: Diabetes Complications, Experimental Diabetes Mellitus, Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus, Diabetes, Gestational, Diabetic Angiopathies, Diabetic Cardiomyopathies, Diabetic Coma, Diabetic Ketoacidosis, Diabetic Nephropathies, Diabetic Neuropathies, Donohue Syndrome, Fetal Macrosomia, and Prediabetic State.