UHPLC-Orbitrap screening of oleraindoles in hydromethanolic extracts of Portulaca oleracea

IF 1.1 Q4 PHARMACOLOGY & PHARMACY
Y. Voynikov, R. Gevrenova, D. Zheleva-Dimitrova, V. Balabanova, Irina Nikolova, Lyubomir Marinov, Iossif Benbassat, G. Momekov
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引用次数: 0

Abstract

Purslane (Portulaca oleracea L., Portulacaceae) is a widespread edible plant with significant ethnobotanical and ethnopharmacological importance. The plant is characteristic for the presence of a class of indoline amide glucoside alkaloids, called cyclo-dopa amides, or oleraceins. Additionally, a new, structurally similar to oleraceins, class of indole amides have been discovered recently, called oleraindoles. These compounds have been evaluated to possess antiinflammatory and anticholinesterase activities. Herein, utilizing UHPLC-Orbitrap-MS with MS2 filtering by diagnostic ion filtering (DIF), and diagnostic difference filtering (DDF) using different data analysis tools, eight compounds with oleraindole structure were tentatively identified.
超高效液相色谱-轨道阱(UHPLC-Orbitrap)筛选马齿苋水甲醇提取物中的欧来吲哚类化合物
马齿苋(马齿苋科马齿苋属植物)是一种广泛食用的植物,在民族植物学和民族药理学方面具有重要意义。该植物的特点是含有一类吲哚啉酰胺葡萄糖苷生物碱,称为环多巴酰胺或马齿苋苷。此外,最近还发现了一类新的、结构上与欧来酰胺相似的吲哚酰胺,称为欧来吲哚。经评估,这些化合物具有抗炎和抗胆碱酯酶活性。本文利用超高效液相色谱-轨道阱质谱(UHPLC-Orbitrap-MS),通过诊断性离子过滤(DIF)和诊断性差异过滤(DDF)等不同的数据分析工具进行MS2过滤,初步鉴定出8种具有欧来烯醇结构的化合物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Pharmacia
Pharmacia PHARMACOLOGY & PHARMACY-
CiteScore
2.30
自引率
27.30%
发文量
114
审稿时长
12 weeks
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