Dynamics of cognitive functions in patients with hemoblastosis treated with hematopoietic stem cell transplantation

T. A. Kuznetsova, I. V. Grandilevskaya, I. Y. Obidin
{"title":"Dynamics of cognitive functions in patients with hemoblastosis treated with hematopoietic stem cell transplantation","authors":"T. A. Kuznetsova, I. V. Grandilevskaya, I. Y. Obidin","doi":"10.23873/2074-0506-2023-15-4-488-498","DOIUrl":null,"url":null,"abstract":"Introduction. The number of bone marrow transplantations is increasing worldwide. However, the issue of cognitive impairments following this procedure in hematologic malignancies remains poorly investigated.Aim. The aim of this study was to investigate the level and dynamics of memory and attention parameters in oncological patients undergoing hematopoietic stem cell transplantation.Material and methods. The study was conducted in three stages: pre-operation and two post-operation stages, on days 21 and 60, with control points corresponding to medical protocol milestones. The study involved 43 patients aged 18 to 62, including 22 males and 21 females.Results. The study revealed that most memory-related parameters were at low levels, which may be attributed to preoperative chemotherapy, and further decreased cognitive functions throughout the study (p=0.014, p=0.082, statistically significant in both cases). Attention assessment results indicated predominantly normal levels, while attention-switching parameters decreased from the second to the third stage of the study (p=0.33). The affective sphere before bone marrow transplantation was characterized by depressive symptoms at the sub-depressive level and upper bounds of situational anxiety. By the third stage of the study, these variables gradually decreased to normal values (p=0.03, p=0.07).Conclusions. In the context of this study, a decline in cognitive functions, including mediated, short-term, long-term, and mechanical memory, was observed. A similar trend was noted in attention concentration and attention-switching capabilities.","PeriodicalId":23229,"journal":{"name":"Transplantologiya. The Russian Journal of Transplantation","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Transplantologiya. The Russian Journal of Transplantation","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.23873/2074-0506-2023-15-4-488-498","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Introduction. The number of bone marrow transplantations is increasing worldwide. However, the issue of cognitive impairments following this procedure in hematologic malignancies remains poorly investigated.Aim. The aim of this study was to investigate the level and dynamics of memory and attention parameters in oncological patients undergoing hematopoietic stem cell transplantation.Material and methods. The study was conducted in three stages: pre-operation and two post-operation stages, on days 21 and 60, with control points corresponding to medical protocol milestones. The study involved 43 patients aged 18 to 62, including 22 males and 21 females.Results. The study revealed that most memory-related parameters were at low levels, which may be attributed to preoperative chemotherapy, and further decreased cognitive functions throughout the study (p=0.014, p=0.082, statistically significant in both cases). Attention assessment results indicated predominantly normal levels, while attention-switching parameters decreased from the second to the third stage of the study (p=0.33). The affective sphere before bone marrow transplantation was characterized by depressive symptoms at the sub-depressive level and upper bounds of situational anxiety. By the third stage of the study, these variables gradually decreased to normal values (p=0.03, p=0.07).Conclusions. In the context of this study, a decline in cognitive functions, including mediated, short-term, long-term, and mechanical memory, was observed. A similar trend was noted in attention concentration and attention-switching capabilities.
接受造血干细胞移植治疗的血液母细胞增多症患者认知功能的动态变化
简介全世界骨髓移植的数量不断增加。然而,对血液系统恶性肿瘤患者在接受骨髓移植后的认知障碍问题的研究仍然很少。本研究旨在调查接受造血干细胞移植的肿瘤患者记忆力和注意力参数的水平和动态变化。研究分三个阶段进行:手术前和手术后两个阶段,分别为第21天和第60天,对照点与医疗方案里程碑相对应。研究涉及 43 名 18 至 62 岁的患者,包括 22 名男性和 21 名女性。研究显示,大多数记忆相关参数处于较低水平,这可能与术前化疗有关,在整个研究过程中认知功能进一步下降(P=0.014,P=0.082,均有统计学意义)。注意力评估结果显示主要处于正常水平,而注意力切换参数从研究的第二阶段到第三阶段有所下降(p=0.33)。骨髓移植前情感领域的特点是抑郁症状处于亚抑郁水平,情境焦虑达到上限。到研究的第三阶段,这些变量逐渐降至正常值(P=0.03,P=0.07)。在本研究中,观察到认知功能下降,包括介导记忆、短期记忆、长期记忆和机械记忆。注意力集中和注意力转换能力也出现了类似的趋势。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信