Treatment Resistance to TNF-α Inhibitors in Patients with Psoriasis

IF 3.7 4区医学 Q1 DERMATOLOGY

Dermatologic Therapy Pub Date : 2023-12-21 DOI:10.1155/2023/7399468

Amirmansoor Gholami, Ahmad Vafaeian, M. Daneshpazhooh, I. Etesami, K. Balighi, Delnavaz Jan, A. Salehi Farid, Ali Vafaei, H. Mahmoudi

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引用次数: 0

Abstract

Background. Treatment resistance to biologic treatment at specific sites in the body is a challenging issue. However, there is insufficient evidence for factors affecting the resistance of these areas to biological therapies. Methods. In this study, patients with moderate-to-severetreatment-resistant psoriasis who were biologic naïve and referred to Razi hospital were included. The relationship between treatment resistance in different areas and demographic and clinical variables was investigated. Results. A total of 131 biologic-naïve patients with psoriasis treated with anti-TNF-α were included in this study. The most common resistant sites included the scalp, anterior lower legs, and elbows. Also, hand- and toe-nail involvements were considerable. BMI, gender, smoking, PASI score, the duration of the disease, the time distance between diagnosis and treatment, and treatment regiments were found to affect the incidence of resistance to treatment in multiple areas, while age, the incidence of recalcitrant disease and/or psoriatic arthritis, and the duration of current treatment did not have effects. Conclusion. The most common refractory sites were the scalp, anterior lower legs, and elbows. This study should be followed up with larger samples containing a variety of biological treatments in order to evaluate the results.

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银屑病患者对 TNF-α 抑制剂的耐药性

背景。体内特定部位对生物疗法的耐药性是一个具有挑战性的问题。然而，目前还没有足够的证据表明影响这些部位对生物疗法产生耐药性的因素。研究方法本研究纳入了转诊至拉齐医院的中度至重度耐药银屑病患者，这些患者均对生物制剂治疗持 "天真 "态度。研究了不同部位的耐药性与人口统计学和临床变量之间的关系。研究结果本研究共纳入了131名接受过抗TNF-α治疗、对生物制剂不敏感的银屑病患者。最常见的耐药部位包括头皮、小腿前侧和肘部。此外，手部和脚趾甲的受累情况也相当严重。研究发现，体重指数（BMI）、性别、吸烟、PASI 评分、病程、诊断与治疗之间的时间间隔以及治疗方案会影响多个部位的耐药发生率，而年龄、顽固性疾病和/或银屑病关节炎的发生率以及当前治疗的持续时间则没有影响。结论最常见的难治部位是头皮、小腿前侧和肘部。本研究应采用含有多种生物治疗方法的更大样本进行后续研究，以评估结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Dermatologic Therapy 医学-皮肤病学

CiteScore

7.00

自引率

8.30%

发文量

711

审稿时长

3 months

期刊介绍： Dermatologic Therapy has been created to fill an important void in the dermatologic literature: the lack of a readily available source of up-to-date information on the treatment of specific cutaneous diseases and the practical application of specific treatment modalities. Each issue of the journal consists of a series of scholarly review articles written by leaders in dermatology in which they describe, in very specific terms, how they treat particular cutaneous diseases and how they use specific therapeutic agents. The information contained in each issue is so practical and detailed that the reader should be able to directly apply various treatment approaches to daily clinical situations. Because of the specific and practical nature of this publication, Dermatologic Therapy not only serves as a readily available resource for the day-to-day treatment of patients, but also as an evolving therapeutic textbook for the treatment of dermatologic diseases.