R. K. Sercundes, G. Molenberghs, G. Verbeke, Clarice G.B. Demétrio, Sila C. da Silva, Rafael A. Moral
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引用次数: 0
Abstract
Longitudinal studies involving nominal outcomes are carried out in various scientific areas. These outcomes are frequently modelled using a generalized linear mixed modelling (GLMM) framework. This widely used approach allows for the modelling of the hierarchy in the data to accommodate different degrees of overdispersion. In this article, a combined model (CM) that takes into account overdispersion and clustering through two separate sets of random effects is formulated. Maximum likelihood estimation with analytic-numerical integration is used to estimate the model parameters. To examine the relative performance of the CM and the GLMM, simulation studies were carried out, exploring scenarios with different sample sizes, types of random effects, and overdispersion. Both models were applied to a real dataset obtained from an experiment in agriculture. We also provide an implementation of these models through SAS code.
各种科学领域都开展了涉及名义结果的纵向研究。这些结果经常使用广义线性混合建模(GLMM)框架进行建模。这种广泛使用的方法允许对数据中的层次结构进行建模,以适应不同程度的过度分散。本文提出了一种组合模型(CM),通过两组独立的随机效应将过度分散和聚类考虑在内。采用最大似然估计法和分析-数值积分法来估计模型参数。为了检验 CM 和 GLMM 的相对性能,进行了模拟研究,探讨了不同样本大小、随机效应类型和过度分散的情况。这两种模型都被应用于从农业实验中获得的真实数据集。我们还通过 SAS 代码提供了这些模型的实现方法。
期刊介绍:
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.