An Assessment of Primary Cardiac Lymphoma: A Rare Case in Indonesia

Sitti Fatimah Hanum, Endang Sri Roostini Hardjolukito, Budiana Tanurahardja, Aninda Dinar Widiantari, Farida Murtiani
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Abstract

Introduction: : Primary cardiac lymphoma (PCL) is an uncommon malignancy with a high mortality rate. The disease is commonly found as non-Hodgkin’s lymphoma (NHL), mainly located in the heart or pericardium. PCL is difficult to diagnose due to its unspecific clinical manifestations. Echocardiography, computed tomography (CT) scanning, and magnetic resonance imaging (MRI) can help in diagnosing PCL, but histopathological examination is the gold standard for a definitive diagnosis. Therefore, this study aimed to compare the case of malignant cardiac lymphoma and MRI with earlier related literature. Case Presentation: This study reported a case of PCL in 52 years old male who came to Cipto Mangunkusumo Hospital with intra cardiac tumour and underwent surgery with median sternotomy. CT scan of the chest showed a mass in the left atrial and no significant abnormalities in other organs. Histopathological examination showed the morphologic feature of diffuse monotonous proliferation of atypical large B lymphocytes. The lymphoma diagnosis was supported by immunohistochemistry including CD20, MUM1, and Ki67 positivity. Conclusions: PCL was difficult to diagnose due to nonspecific clinical manifestations. Immunostaining helped to diagnose more specifically and determine the treatment plan. Histologic finding from PCL was mostly Diffuse Large B-cell lymphoma (DLBCL) and the prognosis was poor. Therefore, identifying the subtype of DLBCL was important for prognostic.
评估原发性心脏淋巴瘤:印度尼西亚的一个罕见病例
简介: :原发性心脏淋巴瘤(PCL)是一种不常见的恶性肿瘤,死亡率很高。该病常见于非霍奇金淋巴瘤(NHL),主要位于心脏或心包。由于 PCL 的临床表现缺乏特异性,因此很难诊断。超声心动图、计算机断层扫描(CT)和磁共振成像(MRI)有助于诊断 PCL,但组织病理学检查才是明确诊断的金标准。因此,本研究旨在将该病例的恶性心脏淋巴瘤和核磁共振成像与早期相关文献进行比较。病例介绍:本研究报告了一例 PCL 病例,患者为 52 岁男性,因心脏内肿瘤来到 Cipto Mangunkusumo 医院,接受了胸骨正中切开术。胸部 CT 扫描显示左心房有肿块,其他器官无明显异常。组织病理学检查显示其形态特征为非典型大 B 淋巴细胞弥漫性单发增生。淋巴瘤的诊断得到了免疫组化的支持,包括 CD20、MUM1 和 Ki67 阳性。结论由于临床表现无特异性,PCL很难诊断。免疫染色有助于做出更明确的诊断并确定治疗方案。PCL 的组织学发现多为弥漫大 B 细胞淋巴瘤(DLBCL),预后较差。因此,确定 DLBCL 的亚型对预后非常重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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