Research on phage λ: a lucky choice

Q1 Medicine

EcoSal Plus Pub Date : 2023-12-22 DOI:10.1128/ecosalplus.esp-0014-2023

D. Lewis, S. Adhya

引用次数: 0

Abstract

ABSTRACT Bacteriophage λ is a paradigm in the field of gene regulation and one of the best-understood systems in genetic regulatory biology. A so-called Genetic Switch determines the mechanisms by which λ transitions to its dual lifestyles—lytic or lysogenic. When λ initiates the lysogenic lifestyle, the phage-encoded CI repressor binds cooperatively to multi-partite operators in a defined pattern that autoregulates repression of phage lytic promoters as well as activation of the lysogenic promoter. The study of this genetic switch and related earlier research on phage λ revealed the main principles of gene expression and regulation in molecular biology. This article describes the underlying molecular details of λ lysogeny, as it is currently understood.

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噬菌体 λ 研究：幸运的选择

摘要噬菌体 λ 是基因调控领域的典范，也是基因调控生物学中最易理解的系统之一。所谓的 "基因开关"（Genetic Switch）决定了λ向其双重生活方式（溶解性或溶酶性）过渡的机制。当 λ 开始溶解生活方式时，噬菌体编码的 CI 抑制剂会以一种确定的模式与多部分操作者合作结合，从而自动调节对噬菌体溶解启动子的抑制以及对溶解启动子的激活。对这种基因开关的研究以及早期对噬菌体λ的相关研究揭示了分子生物学中基因表达和调控的主要原理。本文介绍了目前所了解的λ溶菌酶发生的基本分子细节。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

EcoSal Plus Immunology and Microbiology-Microbiology

CiteScore

12.20

自引率

0.00%

发文量

期刊介绍： EcoSal Plus is the authoritative online review journal that publishes an ever-growing body of expert reviews covering virtually all aspects of E. coli, Salmonella, and other members of the family Enterobacteriaceae and their use as model microbes for biological explorations. This journal is intended primarily for the research community as a comprehensive and continuously updated archive of the entire corpus of knowledge about the enteric bacterial cell. Thoughtful reviews focus on physiology, metabolism, genetics, pathogenesis, ecology, genomics, systems biology, and history E. coli and its relatives. These provide the integrated background needed for most microbiology investigations and are essential reading for research scientists. Articles contain links to E. coli K12 genes on the EcoCyc database site and are available as downloadable PDF files. Images and tables are downloadable to PowerPoint files.