[Mechanisms of the inhibition of the functional activity of the stomach in acute radiation sickness].

Abstract

The functional state of the gastric mucosa in dogs after 12.7 Gy abdominal X-ray irradiation was examined. During the first 7 days after irradiation, hypochylia, decrease of proteolytic activity and the H+ (hydrogen-ion) production in the gastric juice was observed. The gastric mucosal cells of rats were examined after the irradiation with 12 Gy to find out the reason for hypochylia. Possibly the reduction of the number of the gastric mucosal cells and their protein content one day after the irradiation, as well as functional disorders of the outer membrane--expressed by the decrease of the intracellular K+ (potassium-ion) level and the ATPase and 5'-nucleotidase activity--may be the reasons for the hypochylia after irradiation.