Guilherme A. Pimentel, Laurent Dewasme, Alain Vande Wouwer
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引用次数: 0
Abstract
Following the recent advent of Process Analytical Technologies, dataset production has undergone significant leverage. In this new abundance of data, isolating meaningful, informative content is critical for process dynamic modeling. This paper proposes a data-driven algorithm based on low-rank matrix approximation, the so-called successive projection algorithm, to retrieve a minimal set of macroscopic reactions, the corresponding stoichiometry, and a consistent kinetic model structure from the measurements of the trajectories of the species concentrations during cultures in a bioreactor. The proposed method is successfully validated in simulation, considering a case study related to monoclonal antibody (MAb) production with hybridoma cell cultures.
期刊介绍：
This international journal covers the application of control theory, operations research, computer science and engineering principles to the solution of process control problems. In addition to the traditional chemical processing and manufacturing applications, the scope of process control problems involves a wide range of applications that includes energy processes, nano-technology, systems biology, bio-medical engineering, pharmaceutical processing technology, energy storage and conversion, smart grid, and data analytics among others.
Papers on the theory in these areas will also be accepted provided the theoretical contribution is aimed at the application and the development of process control techniques.
Topics covered include:
• Control applications• Process monitoring• Plant-wide control• Process control systems• Control techniques and algorithms• Process modelling and simulation• Design methods
Advanced design methods exclude well established and widely studied traditional design techniques such as PID tuning and its many variants. Applications in fields such as control of automotive engines, machinery and robotics are not deemed suitable unless a clear motivation for the relevance to process control is provided.
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