PTBP1 as a potential regulator of disease.

IF 3.5 2区 生物学 Q3 CELL BIOLOGY
Molecular and Cellular Biochemistry Pub Date : 2024-11-01 Epub Date: 2023-12-22 DOI:10.1007/s11010-023-04905-x
Qi Yu, Tongtong Wu, Wenhong Xu, Junyuan Wei, Anqi Zhao, Miaomiao Wang, Meiying Li, Guangfan Chi
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引用次数: 0

Abstract

Polypyrimidine tract-binding protein 1 (PTBP1) is a member of the heterogeneous nuclear ribonucleoprotein (hnRNP) family, which plays a key role in alternative splicing of precursor mRNA and RNA metabolism. PTBP1 is universally expressed in various tissues and binds to multiple downstream transcripts to interfere with physiological and pathological processes such as the tumor growth, body metabolism, cardiovascular homeostasis, and central nervous system damage, showing great prospects in many fields. The function of PTBP1 involves the regulation and interaction of various upstream molecules, including circular RNAs (circRNAs), microRNAs (miRNAs) and long non-coding RNAs (lncRNAs). These regulatory systems are inseparable from the development and treatment of diseases. Here, we review the latest knowledge regarding the structure and molecular functions of PTBP1 and summarize its functions and mechanisms of PTBP1 in various diseases, including controversial studies. Furthermore, we recommend future studies on PTBP1 and discuss the prospects of targeting PTBP1 in new clinical therapeutic approaches.

Abstract Image

作为疾病潜在调节因子的 PTBP1。
多嘧啶束结合蛋白1(PTBP1)是异质性核核糖核蛋白(hnRNP)家族的成员,在前体mRNA的替代剪接和RNA代谢中起着关键作用。PTBP1 在各种组织中普遍表达,与多种下游转录本结合,干扰肿瘤生长、机体代谢、心血管稳态和中枢神经系统损伤等生理和病理过程,在许多领域显示出巨大的应用前景。PTBP1 的功能涉及多种上游分子的调控和相互作用,包括环状 RNA(circRNA)、microRNA(miRNA)和长非编码 RNA(lncRNA)。这些调控系统与疾病的发展和治疗密不可分。在此,我们回顾了有关 PTBP1 结构和分子功能的最新知识,并总结了 PTBP1 在各种疾病中的功能和机制,包括有争议的研究。此外,我们还对 PTBP1 的未来研究提出了建议,并探讨了以 PTBP1 为靶点的新临床治疗方法的前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Molecular and Cellular Biochemistry
Molecular and Cellular Biochemistry 生物-细胞生物学
CiteScore
8.30
自引率
2.30%
发文量
293
审稿时长
1.7 months
期刊介绍: Molecular and Cellular Biochemistry: An International Journal for Chemical Biology in Health and Disease publishes original research papers and short communications in all areas of the biochemical sciences, emphasizing novel findings relevant to the biochemical basis of cellular function and disease processes, as well as the mechanics of action of hormones and chemical agents. Coverage includes membrane transport, receptor mechanism, immune response, secretory processes, and cytoskeletal function, as well as biochemical structure-function relationships in the cell. In addition to the reports of original research, the journal publishes state of the art reviews. Specific subjects covered by Molecular and Cellular Biochemistry include cellular metabolism, cellular pathophysiology, enzymology, ion transport, lipid biochemistry, membrane biochemistry, molecular biology, nuclear structure and function, and protein chemistry.
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