Liposome-Mediated Anti-Viral Drug Delivery Across Blood-Brain Barrier: Can Lipid Droplet Target Be Game Changers?

IF 3.6 4区医学 Q3 CELL BIOLOGY

Cellular and Molecular Neurobiology Pub Date : 2023-12-20 DOI:10.1007/s10571-023-01443-4

Sourav Mondal, Sourish Ghosh

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Abstract

Lipid droplets (LDs) are subcellular organelles secreted from the endoplasmic reticulum (ER) that play a major role in lipid homeostasis. Recent research elucidates additional roles of LDs in cellular bioenergetics and innate immunity. LDs activate signaling cascades for interferon response and secretion of pro-inflammatory cytokines. Since balanced lipid homeostasis is critical for neuronal health, LDs play a crucial role in neurodegenerative diseases. RNA viruses enhance the secretion of LDs to support various phases of their life cycle in neurons which further leads to neurodegeneration. Targeting the excess LD formation in the brain could give us a new arsenal of antiviral therapeutics against neuroviruses. Liposomes are a suitable drug delivery system that could be used for drug delivery in the brain by crossing the Blood-Brain Barrier. Utilizing this, various pharmacological inhibitors and non-coding RNAs can be delivered that could inhibit the biogenesis of LDs or reduce their sizes, reversing the excess lipid-related imbalance in neurons. Liposome-Mediated Antiviral Drug Delivery Across Blood-Brain Barrier. Developing effective antiviral drug is challenging and it doubles against neuroviruses that needs delivery across the Blood-Brain Barrier (BBB). Lipid Droplets (LDs) are interesting targets for developing antivirals, hence targeting LD formation by drugs delivered using Liposomes can be game changers.

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脂质体介导的血脑屏障抗病毒药物递送：脂滴靶点能否改变游戏规则？

脂滴（LDs）是内质网（ER）分泌的亚细胞器，在脂质平衡中发挥着重要作用。最新研究阐明了脂滴在细胞生物能和先天性免疫中的其他作用。低密度脂蛋白可激活干扰素反应和促炎细胞因子分泌的信号级联。由于平衡的脂质平衡对神经元的健康至关重要，因此低密度脂蛋白在神经退行性疾病中发挥着关键作用。RNA 病毒会增强低密度脂蛋白的分泌，以支持其在神经元中生命周期的各个阶段，从而进一步导致神经退行性疾病。针对大脑中过量 LD 的形成，可以为我们提供针对神经病毒的新的抗病毒疗法。脂质体是一种合适的给药系统，可用于穿过血脑屏障在大脑中给药。利用这种方法，可以输送各种药理抑制剂和非编码 RNA，从而抑制 LDs 的生物生成或缩小其大小，扭转神经元中与脂质相关的过度失衡。脂质体介导的跨血脑屏障抗病毒药物递送。开发有效的抗病毒药物极具挑战性，它能加倍对抗需要通过血脑屏障（BBB）输送的神经病毒。脂滴（LDs）是开发抗病毒药物的有趣靶点，因此使用脂质体递送药物来靶向形成脂滴可能会改变游戏规则。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cellular and Molecular Neurobiology 生物-神经科学

CiteScore

7.70

自引率

0.00%

发文量

137

审稿时长

4-8 weeks

期刊介绍： Cellular and Molecular Neurobiology publishes original research concerned with the analysis of neuronal and brain function at the cellular and subcellular levels. The journal offers timely, peer-reviewed articles that describe anatomic, genetic, physiologic, pharmacologic, and biochemical approaches to the study of neuronal function and the analysis of elementary mechanisms. Studies are presented on isolated mammalian tissues and intact animals, with investigations aimed at the molecular mechanisms or neuronal responses at the level of single cells. Cellular and Molecular Neurobiology also presents studies of the effects of neurons on other organ systems, such as analysis of the electrical or biochemical response to neurotransmitters or neurohormones on smooth muscle or gland cells.