Treatable traits in asthma during pregnancy: a call for a shift towards a precision-based management approach

IF 9 1区医学 Q1 RESPIRATORY SYSTEM

European Respiratory Review Pub Date : 2023-12-20 DOI:10.1183/16000617.0105-2023

Esha Joshi, Peter G. Gibson, Vanessa M. McDonald, Vanessa E. Murphy

{"title":"Treatable traits in asthma during pregnancy: a call for a shift towards a precision-based management approach","authors":"Esha Joshi, Peter G. Gibson, Vanessa M. McDonald, Vanessa E. Murphy","doi":"10.1183/16000617.0105-2023","DOIUrl":null,"url":null,"abstract":"<p>Asthma is the most common chronic medical condition in pregnancy. Asthma exacerbations in pregnancy are unpredictable, and are associated with adverse maternal and fetal perinatal outcomes such as preterm birth and low birthweight. Goals of asthma management in pregnancy are to establish effective asthma control and prevent exacerbations. Optimising the management of asthma in pregnancy is an important goal of practice and future research.</p>\n<p>Treatable traits is a precision medicine paradigm proposed for the management of airways diseases, which holistically addresses the complexity and heterogeneity of airways disease. It is an individualised treatment approach that aims to improve outcomes. This makes treatable traits well suited for pregnant women with asthma, who have a high prevalence of obesity, mental health conditions, poor symptom perception and suboptimal asthma management skills including low treatment adherence. These traits are measurable and treatable. In this review, we explore current knowledge on the burden of asthma, maternal and perinatal consequences of asthma during pregnancy, the treatable traits paradigm, the prevalence of treatable traits in pregnant women with asthma, and consider how the treatable traits paradigm can be integrated into the management of asthma in pregnancy.</p>","PeriodicalId":12166,"journal":{"name":"European Respiratory Review","volume":"198 1","pages":""},"PeriodicalIF":9.0000,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Respiratory Review","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1183/16000617.0105-2023","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"RESPIRATORY SYSTEM","Score":null,"Total":0}

引用次数: 0

Abstract

Asthma is the most common chronic medical condition in pregnancy. Asthma exacerbations in pregnancy are unpredictable, and are associated with adverse maternal and fetal perinatal outcomes such as preterm birth and low birthweight. Goals of asthma management in pregnancy are to establish effective asthma control and prevent exacerbations. Optimising the management of asthma in pregnancy is an important goal of practice and future research.

Treatable traits is a precision medicine paradigm proposed for the management of airways diseases, which holistically addresses the complexity and heterogeneity of airways disease. It is an individualised treatment approach that aims to improve outcomes. This makes treatable traits well suited for pregnant women with asthma, who have a high prevalence of obesity, mental health conditions, poor symptom perception and suboptimal asthma management skills including low treatment adherence. These traits are measurable and treatable. In this review, we explore current knowledge on the burden of asthma, maternal and perinatal consequences of asthma during pregnancy, the treatable traits paradigm, the prevalence of treatable traits in pregnant women with asthma, and consider how the treatable traits paradigm can be integrated into the management of asthma in pregnancy.

查看原文本刊更多论文

妊娠期哮喘的可治疗特征：呼吁向精确管理方法转变

哮喘是孕期最常见的慢性疾病。妊娠期哮喘的恶化是不可预测的，并且与孕产妇和胎儿围产期的不良后果有关，如早产和出生体重过轻。妊娠期哮喘管理的目标是建立有效的哮喘控制并预防病情恶化。优化妊娠期哮喘管理是实践和未来研究的重要目标。"可治疗性状 "是针对气道疾病管理提出的一种精准医学范式，它从整体上解决了气道疾病的复杂性和异质性。它是一种个体化治疗方法，旨在改善治疗效果。这使得可治疗特质非常适合患有哮喘的孕妇，因为她们肥胖率高、精神健康状况差、症状感知能力差、哮喘管理技能不理想，包括治疗依从性低。这些特征是可测量和可治疗的。在这篇综述中，我们将探讨有关哮喘负担、妊娠期哮喘对孕产妇和围产期的影响、可治疗特质范式、可治疗特质在哮喘孕妇中的流行率等方面的现有知识，并考虑如何将可治疗特质范式纳入妊娠期哮喘的管理中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

European Respiratory Review Medicine-Pulmonary and Respiratory Medicine

CiteScore

14.40

自引率

1.30%

发文量

审稿时长

24 weeks

期刊介绍： The European Respiratory Review (ERR) is an open-access journal published by the European Respiratory Society (ERS), serving as a vital resource for respiratory professionals by delivering updates on medicine, science, and surgery in the field. ERR features state-of-the-art review articles, editorials, correspondence, and summaries of recent research findings and studies covering a wide range of topics including COPD, asthma, pulmonary hypertension, interstitial lung disease, lung cancer, tuberculosis, and pulmonary infections. Articles are published continuously and compiled into quarterly issues within a single annual volume.