Metabolomics in diabetes mellitus: clinical insight.

IF 3.8 3区生物学 Q1 BIOCHEMICAL RESEARCH METHODS

Expert Review of Proteomics Pub Date : 2023-07-01 Epub Date: 2023-12-30 DOI:10.1080/14789450.2023.2295866

Shereen M Aleidi, Hiba Al Fahmawi, Afshan Masoud, Anas Abdel Rahman

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引用次数: 0

Abstract

Introduction: Diabetes Mellitus (DM) is a chronic heterogeneous metabolic disorder characterized by hyperglycemia due to the destruction of insulin-producing pancreatic β cells and/or insulin resistance. It is now considered a global epidemic disease associated with serious threats to a patient's life. Understanding the metabolic pathways involved in disease pathogenesis and progression is important and would improve prevention and management strategies. Metabolomics is an emerging field of research that offers valuable insights into the metabolic perturbation associated with metabolic diseases, including DM.

Area covered: Herein, we discussed the metabolomics in type 1 and 2 DM research, including its contribution to understanding disease pathogenesis and identifying potential novel biomarkers clinically useful for disease screening, monitoring, and prognosis. In addition, we highlighted the metabolic changes associated with treatment effects, including insulin and different anti-diabetic medications.

Expert opinion: By analyzing the metabolome, the metabolic disturbances involved in T1DM and T2DM can be explored, enhancing our understanding of the disease progression and potentially leading to novel clinical diagnostic and effective new therapeutic approaches. In addition, identifying specific metabolites would be potential clinical biomarkers for predicting the disease and thus preventing and managing hyperglycemia and its complications.

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糖尿病的代谢组学：临床见解。

简介糖尿病（Diabetes Mellitus，DM）是一种慢性异质性代谢紊乱疾病，其特征是由于胰岛素分泌的胰腺β细胞遭到破坏和/或胰岛素抵抗导致的高血糖。目前，它已被视为一种全球性流行疾病，严重威胁着患者的生命。了解疾病发病和发展过程中的代谢途径非常重要，有助于改善预防和管理策略。代谢组学是一个新兴的研究领域，它为了解与代谢性疾病（包括 DM）相关的代谢扰动提供了宝贵的见解：在本文中，我们讨论了代谢组学在 1 型和 2 型 DM 研究中的应用，包括其对了解疾病发病机制的贡献，以及确定对疾病筛查、监测和预后具有临床价值的潜在新型生物标记物。此外，我们还强调了与治疗效果相关的代谢变化，包括胰岛素和不同的抗糖尿病药物：专家观点：通过分析代谢组，可以探索 T1DM 和 T2DM 所涉及的代谢紊乱，从而加深我们对疾病进展的了解，并有可能开发出新型临床诊断方法和有效的新疗法。此外，确定特定的代谢物将成为预测疾病的潜在临床生物标志物，从而预防和控制高血糖及其并发症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Expert Review of Proteomics 生物-生化研究方法

CiteScore

7.60

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Expert Review of Proteomics (ISSN 1478-9450) seeks to collect together technologies, methods and discoveries from the field of proteomics to advance scientific understanding of the many varied roles protein expression plays in human health and disease. The journal coverage includes, but is not limited to, overviews of specific technological advances in the development of protein arrays, interaction maps, data archives and biological assays, performance of new technologies and prospects for future drug discovery. The journal adopts the unique Expert Review article format, offering a complete overview of current thinking in a key technology area, research or clinical practice, augmented by the following sections: Expert Opinion - a personal view on the most effective or promising strategies and a clear perspective of future prospects within a realistic timescale Article highlights - an executive summary cutting to the author''s most critical points.

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