Clinicopathological features of colorectal cancer patients under 30 years of age.

Cirugia y cirujanos Pub Date : 2023-01-01 DOI:10.24875/CIRU.22000467

Horacio N López-Basave, Flavia Morales-Vázquez, Gerardo Miranda-Dévora, Juan P Olmos-García, Karla F Hernández-Castañeda, Luis G Rivera-Mogollan, Wendy R Muñoz-Montaño

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Abstract

Background: Colorectal cancer (CRC) is the second cause of cancer death in the world and is estimated to have been responsible for almost 935,000 deaths during 2020.

Objective: Describe clinicopathological features, overall survival (OS) and progression-free survival (PFS) in CRC patients under 30 years.

Method: This is a retrospective cohort study in patients under 30 years diagnosed with CRC.

Results: From 2017 to 2021, 1823 patients were diagnosed with CRC, of which 54 (2.96%) were under 30 years. The OS, during 4 years, was 41.5%. The clinical stage found IV (hazard ratio [HR]: 6.212; 95% confidence interval [95% CI]: 2.504-15.414; p < 0.001), giving neoadjuvant therapy (HR: 0.705; 95% CI: 0.499-0.996; p = 0.047) and no medical history of Lynch syndrome (HR: 3.925; 95% CI: 1.355-11.364; p = 0.012) are independent predictors of mortality. The PFS, during 4 years, was 21.3%. Clinical stage IV (HR: 2.418; 95% CI: 1.000-5.850; p < 0.050), and no diagnosis of Lynch syndrome (HR: 3.800; 95% CI: 1.398-10.326; p = 0.009) are independent predictors.

Conclusions: Younger patients are usually diagnosed with CRC in advanced stages. Early symptoms and evaluation, irrespective of age, are crucial.

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30 岁以下结直肠癌患者的临床病理特征。

背景：结直肠癌（CRC）是全球第二大癌症死因，据估计，2020年将有近93.5万人死于此病：描述30岁以下CRC患者的临床病理特征、总生存期（OS）和无进展生存期（PFS）：这是一项针对30岁以下确诊为CRC患者的回顾性队列研究：2017年至2021年，共有1823名CRC患者被确诊，其中30岁以下患者54名（2.96%）。4年间的OS为41.5%。临床分期为 IV 期（危险比 [HR]：6.212；95% 置信区间 [95%CI]：2.504-15.414；P < 0.001）、接受新辅助治疗（HR：0.705；95% CI：0.499-0.996；P = 0.047）和无林奇综合征病史（HR：3.925；95% CI：1.355-11.364；P = 0.012）是死亡率的独立预测因素。4年间的PFS为21.3%。临床Ⅳ期（HR：2.418；95% CI：1.000-5.850；P <0.050）和未确诊林奇综合征（HR：3.800；95% CI：1.398-10.326；P = 0.009）是独立的预测因素：结论：年轻患者通常在晚期才被确诊为 CRC。无论年龄大小，早期症状和评估都至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Cirugia y cirujanos

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