[The search for the "node of life": breathing regulation].

IF 1.2 Q4 RESPIRATORY SYSTEM
Pneumologie Pub Date : 2024-04-01 Epub Date: 2023-12-14 DOI:10.1055/a-2215-2937
Ulrich Koehler, Mikail Aykut Degerli, Regina Conradt, Olaf Hildebrandt, Niklas Koehler, Wulf Hildebrandt
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引用次数: 0

Abstract

The article provides a historical overview of developments in the understanding of respiratory rhythm and its control mechanisms over the last two centuries. In the 19th century, a structure in the medulla oblongata was first described as the "node of life". In 1743, Taube discovered the carotid body, and in 1927 the Spaniard de Castro described its morphology and innervation. It was only with the work of father and son Heymans that the physiological and pharmacological significance of the carotid and aortic body was recognized. Today we understand that the generation and control of respiration are mediated by a complex neuronal network in the brainstem. Chemo-, mechano- and proprioreceptos convey information from blood, airways and muscles to the control centre. The respiratory centre integrates the afferent input from the receptors, the autonomic nervous system, the cardiovascular system, and voluntary input from the cerebral cortex to modulate the degree of respiratory activation of motoneurons and respiratory muscles.

[寻找 "生命节点":呼吸调节]。
文章从历史角度概述了过去两个世纪以来人们对呼吸节律及其控制机制的认识发展。19 世纪,延髓中的一个结构首次被描述为 "生命节点"。1743 年,陶贝发现了颈动脉体,1927 年,西班牙人德-卡斯特罗描述了颈动脉体的形态和神经支配。直到海曼斯父子的研究,人们才认识到颈动脉和主动脉体的生理和药理意义。今天,我们知道呼吸的产生和控制是由脑干中复杂的神经元网络介导的。化学、机械和本体感受器将来自血液、气道和肌肉的信息传递给控制中心。呼吸中枢整合来自感受器、自主神经系统、心血管系统的传入信息,以及来自大脑皮层的自主信息,从而调节运动神经元和呼吸肌的呼吸激活程度。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Pneumologie
Pneumologie RESPIRATORY SYSTEM-
CiteScore
1.80
自引率
16.70%
发文量
416
期刊介绍: Organ der Deutschen Gesellschaft für Pneumologie DGP Organ des Deutschen Zentralkomitees zur Bekämpfung der Tuberkulose DZK Organ des Bundesverbandes der Pneumologen BdP Fachärzte für Lungen- und Bronchialheilkunde, Pneumologen und Allergologen
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