Protective effects of hydro-alcoholic extract of Zataria multiflora on lipopolysaccharide-induced inflammation and oxidative stress in rat liver.

IF 1.9 Q3 CHEMISTRY, MEDICINAL

Avicenna Journal of Phytomedicine Pub Date : 2023-09-01 DOI:10.22038/AJP.2023.21914

Zohreh Arab, Hossein Salmani, Narges Marefati, Farimah Beheshti, Akbar Anaeigoudari, Farzaneh Shakeri, Narges Tajmazinani, Mahmoud Hosseini

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引用次数: 0

Abstract

Objective: Liver is an important player in regulation of body homeostasis. Study investigated the effects of hydro-alcohol extract of Zataria multiflora (ZM) on oxidative damage, level of IL-6 and enzymes of liver in lipopolysaccharide (LPS)-treated rats.

Materials and methods: The rats were distributed into 5 groups: 1) Control; 2) LPS; and 3-5) ZM-Extract (Ext) 50, ZM-Ext 100, and ZM-Ext 200. ZM-Ext groups received 50, 100 and 200 mg/kg of extract 30 min before LPS. Drugs were injected intraperitoneally. The entire period of this project was 17 days. In first three days, only extract was injected and then, ZM was injected along with LPS.

Results: LPS increased the level of ALT (Alanine aminotransferase), AST (Aspartate aminotransferase ), ALK-P (Alkaline Phosphatase), IL-6, malondialdehyde (MDA), and nitric oxide (NO) metabolites and lowered thiol, superoxide dismutase (SOD) and catalase (CAT) concentration. ZM extract not only reduced ALT, AST, ALK-P, IL-6, MDA, and NO metabolites concentrations but also increased thiol content, and SOD and CAT levels.

Conclusion: Extract of ZM prevented LPS-induced hepatotoxicity. This protective effect was associated with reduction in inflammation and oxidative stress.

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多花月见草水醇提取物对脂多糖诱导的大鼠肝脏炎症和氧化应激的保护作用

目的肝脏是调节体内平衡的重要器官。本研究探讨了多花蓼水醇提取物（ZM）对脂多糖（LPS）处理大鼠肝脏氧化损伤、IL-6 水平和酶的影响：大鼠分为 5 组：1）对照组；2）LPS 组；3-5）ZM-提取物组。ZM-Ext 50、ZM-Ext 100 和 ZM-Ext 200。ZM-Ext组在LPS发生前30分钟接受50、100和200毫克/千克的提取物。药物经腹腔注射。整个项目为期 17 天。前三天只注射提取物，然后在注射 LPS 的同时注射 ZM：结果：LPS 增加了 ALT（丙氨酸氨基转移酶）、AST（天冬氨酸氨基转移酶）、ALK-P（碱性磷酸酶）、IL-6、丙二醛（MDA）和一氧化氮（NO）代谢物的水平，降低了硫醇、超氧化物歧化酶（SOD）和过氧化氢酶（CAT）的浓度。ZM 提取物不仅能降低 ALT、AST、ALK-P、IL-6、MDA 和 NO 代谢物浓度，还能提高硫醇含量、SOD 和 CAT 水平：结论：ZM 提取物可预防 LPS 诱导的肝毒性。这种保护作用与炎症和氧化应激的减少有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Avicenna Journal of Phytomedicine CHEMISTRY, MEDICINAL-

CiteScore

3.40

自引率

4.50%

发文量

审稿时长

6 weeks