{"title":"Proliferative response of blood cells of patients with myasthenia gravis to purified mammalian acetylcholine receptor.","authors":"A Sisely, R P Lisak, T Brenner","doi":"10.1159/000157142","DOIUrl":null,"url":null,"abstract":"<p><p>We employed a purified mammalian (fetal calf) acetylcholine receptor (AChR) preparation to compare proliferation of peripheral blood mononuclear cells (PBMC) of patients with myasthenia gravis (MG) (n = 8) and normal controls (n = 6). PBMC of patients with MG demonstrated an enhanced proliferative response to AChR when compared to controls (mean stimulation index (SI) of 4.2 +/- 1.5 (SD) vs. 1.1 +/- 0.6; p less than 0.01) but no difference in the response to tetanus toxoid (7.1 +/- 3.9 vs. 11.1 +/- 10.8). These results suggest that MG patients exhibit a presumptive T-cell response to purified mammalian AChR that is not found in normal subjects. The nature of the proliferating cell and the interaction with B cells producing anti-AChR antibodies remain to be determined.</p>","PeriodicalId":77765,"journal":{"name":"Pathology and immunopathology research","volume":"8 2","pages":"113-7"},"PeriodicalIF":0.0000,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000157142","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pathology and immunopathology research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1159/000157142","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 3
Abstract
We employed a purified mammalian (fetal calf) acetylcholine receptor (AChR) preparation to compare proliferation of peripheral blood mononuclear cells (PBMC) of patients with myasthenia gravis (MG) (n = 8) and normal controls (n = 6). PBMC of patients with MG demonstrated an enhanced proliferative response to AChR when compared to controls (mean stimulation index (SI) of 4.2 +/- 1.5 (SD) vs. 1.1 +/- 0.6; p less than 0.01) but no difference in the response to tetanus toxoid (7.1 +/- 3.9 vs. 11.1 +/- 10.8). These results suggest that MG patients exhibit a presumptive T-cell response to purified mammalian AChR that is not found in normal subjects. The nature of the proliferating cell and the interaction with B cells producing anti-AChR antibodies remain to be determined.
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