Reduction of the trans-cortical vessel was associated with bone loss, another underlying mechanism of osteoporosis

IF 2.9 4区医学 Q2 PERIPHERAL VASCULAR DISEASE

Microvascular research Pub Date : 2023-12-18 DOI:10.1016/j.mvr.2023.104650

Chun-Lin Xiao , Lu-Lin Liu , Wen Tang , Wu-Yang Liu , Long-Yan Wu , Kai Zhao

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Abstract

Rationale

Numerous studies have established a robust association between bone morrow microvascular diseases and osteoporosis. This study sought to investigate the relationship between alterations in trans-cortical vessel (TCVs) and the onset of osteoporosis in various mouse models.

Methods

Aged mice, ovariectomized mice, and db/db mice, were utilized as osteoporosis models. TCVs in the tibia were detected using tissue clearing and light sheet fluorescence microscopy imaging. Femurs bone mass were analyzed using micro-CT scanning. Correlations between the number of TCVs and bone mass were analyzed using Pearson correlation analysis.

Results

All osteoporosis mouse models showed a significant reduction in the number of TCVs compared to the control group. Correlation analysis revealed a positive association between the number of TCVs and bone mass. TCVs were also expressed high levels of CD31 and EMCN proteins as type H vessels.

Conclusions

This study underscores a consistent correlation between the number of TCVs and bone mass. Moreover, TCVs may serve as a potential biomarker for bone mass evaluation.

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跨皮质血管的减少与骨质流失有关，这是骨质疏松症的另一个潜在机制

理论依据大量研究证实，骨髓微血管疾病与骨质疏松症之间存在密切联系。本研究试图探讨跨皮质血管（TCVs）的改变与不同小鼠模型中骨质疏松症发病之间的关系。方法利用老年小鼠、卵巢切除小鼠和 db/db 小鼠作为骨质疏松症模型。采用组织清除和光片荧光显微镜成像技术检测胫骨中的 TCV。使用显微 CT 扫描分析股骨的骨量。结果与对照组相比，所有骨质疏松症小鼠模型的TCV数量都显著减少。相关分析表明，TCVs 的数量与骨量呈正相关。结论这项研究强调了 TCVs 的数量与骨量之间存在一致的相关性。此外，TCV 可作为骨量评估的潜在生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Microvascular research 医学-外周血管病

CiteScore

6.00

自引率

3.20%

发文量

158

审稿时长

43 days

期刊介绍： Microvascular Research is dedicated to the dissemination of fundamental information related to the microvascular field. Full-length articles presenting the results of original research and brief communications are featured. Research Areas include: • Angiogenesis • Biochemistry • Bioengineering • Biomathematics • Biophysics • Cancer • Circulatory homeostasis • Comparative physiology • Drug delivery • Neuropharmacology • Microvascular pathology • Rheology • Tissue Engineering.