CYP-catalysed Cycling of Clozapine and Clozapine-N-oxide Promotes the Generation of Reactive Oxygen Species in vitro.

IF 1.3 4区医学 Q4 PHARMACOLOGY & PHARMACY

Xenobiotica Pub Date : 2023-12-18 DOI:10.1080/00498254.2023.2294473

Ellen Kingston, Malcolm Tingle, Brandi L. Bellissima, Nuala Helsby, Kathryn Burns

引用次数: 0

Abstract

Clozapine is an effective atypical antipsychotic indicated for treatment-resistant schizophrenia but is under-prescribed due to the risk of severe adverse drug reactions such as myocarditis. A mech...

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CYP 催化的氯氮平与氯氮平-N-氧化物的体外循环促进了活性氧的生成。

氯氮平是一种有效的非典型抗精神病药，适用于治疗耐药性精神分裂症，但由于存在心肌炎等严重药物不良反应的风险，其用药量一直不足。一种机...

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Xenobiotica 医学-毒理学

CiteScore

3.80

自引率

5.60%

发文量

审稿时长

2 months

期刊介绍： Xenobiotica covers seven main areas, including:General Xenobiochemistry, including in vitro studies concerned with the metabolism, disposition and excretion of drugs, and other xenobiotics, as well as the structure, function and regulation of associated enzymesClinical Pharmacokinetics and Metabolism, covering the pharmacokinetics and absorption, distribution, metabolism and excretion of drugs and other xenobiotics in manAnimal Pharmacokinetics and Metabolism, covering the pharmacokinetics, and absorption, distribution, metabolism and excretion of drugs and other xenobiotics in animalsPharmacogenetics, defined as the identification and functional characterisation of polymorphic genes that encode xenobiotic metabolising enzymes and transporters that may result in altered enzymatic, cellular and clinical responses to xenobioticsMolecular Toxicology, concerning the mechanisms of toxicity and the study of toxicology of xenobiotics at the molecular levelXenobiotic Transporters, concerned with all aspects of the carrier proteins involved in the movement of xenobiotics into and out of cells, and their impact on pharmacokinetic behaviour in animals and manTopics in Xenobiochemistry, in the form of reviews and commentaries are primarily intended to be a critical analysis of the issue, wherein the author offers opinions on the relevance of data or of a particular experimental approach or methodology