Risk-stratified thromboprophylaxis effects of aspirin versus low-molecular-weight heparin in orthopaedic trauma patients: a secondary analysis of the PREVENT CLOT trial.
Nathan N O'Hara, Robert V O'Toole, Katherine P Frey, Renan C Castillo, Joseph Cuschieri, Elliott R Haut, Gerard P Slobogean, Reza Firoozabadi, Ashley Christmas, William T Obremskey, Anthony R Carlini, Greg Gaski, Matthew E Kutcher, Debra Marvel, Deborah M Stein
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Abstract
The PREVENT CLOT trial concluded that thromboprophylaxis with aspirin was noninferior to low-molecular-weight heparin (LMWH) in preventing death after orthopaedic trauma. However, it was unclear if these results applied to patients at highest risk of thrombosis. Therefore, we assessed if the effect of aspirin versus LMWH differed based on patients' baseline risk of venous thromboembolism (VTE).
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