Pituitary apoplexy in endocrinologically silent adenoma during somatostatin analog administration for pancreatic neuroendocrine tumor: A case report

IF 1.3 4区医学 Q4 CLINICAL NEUROLOGY

Neuropathology Pub Date : 2023-12-15 DOI:10.1111/neup.12959

Keitaro Shiraishi, Takuya Akai, Takahiro Tomita, Ryuji Hayashi, Takashi Minamisaka, Satoshi Kuroda

引用次数: 0

Abstract

A dopamine agonist administered for prolactinoma treatment and pituitary stimulation tests are reported as risk factors for pituitary apoplexy. We report a case of an 82-year-old patient who suffered from pituitary apoplexy in an endocrinologically silent adenoma during lanreotide administration. The patient was diagnosed with a pancreatic neuroendocrine tumor with lymph node metastasis and treated with lanreotide for two years. An endoscopic endonasal transsphenoidal approach was used for tumor and hematoma removal. The specimen showed growth hormone and prolactin positivity and was diagnosed as pit1-lineage plurihormonal adenoma. The tumor also showed positivity for somatostatin receptor 2. Thus, lanreotide treatment is a risk factor for pituitary apoplexy even in silent adenoma.

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在使用体生长抑素类似物治疗胰腺神经内分泌肿瘤期间，内分泌学上沉默的腺瘤出现垂体中风：病例报告

据报道，为治疗泌乳素瘤而使用的多巴胺激动剂和垂体刺激试验是垂体中风的危险因素。我们报告了一例 82 岁的患者在服用兰瑞奥肽期间因内分泌无症状腺瘤导致垂体中风的病例。患者被诊断为胰腺神经内分泌肿瘤并伴有淋巴结转移，接受了两年的兰瑞奥肽治疗。患者采用内镜下经鼻蝶窦方法切除肿瘤和血肿。标本显示生长激素和催乳素阳性，被诊断为pit1系多激素腺瘤。肿瘤还显示体生长抑素受体2阳性。因此，即使是无声腺瘤，兰瑞肽治疗也是垂体卒中的一个危险因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuropathology 医学-病理学

CiteScore

4.10

自引率

4.30%

发文量

105

审稿时长

6-12 weeks

期刊介绍： Neuropathology is an international journal sponsored by the Japanese Society of Neuropathology and publishes peer-reviewed original papers dealing with all aspects of human and experimental neuropathology and related fields of research. The Journal aims to promote the international exchange of results and encourages authors from all countries to submit papers in the following categories: Original Articles, Case Reports, Short Communications, Occasional Reviews, Editorials and Letters to the Editor. All articles are peer-reviewed by at least two researchers expert in the field of the submitted paper.