Elucidation of Tartaric Acid-Assisted Supersaturation Maintenance of Dipyridamole by Eudragit® E100

IF 2.7 4区医学 Q2 PHARMACOLOGY & PHARMACY

Journal of Pharmaceutical Innovation Pub Date : 2023-12-16 DOI:10.1007/s12247-023-09798-3

Maryam Maghsoodi, Vahid Baghcheh, Mohammad Feyzizadeh, Ashkan Barfar, Ali Nokhodchi

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Abstract

Purpose

The purpose of this study was to investigate the effect of tartaric acid on the maintenance of dipyridamole supersaturation using Eudragit E100 as a carrier.

Methods

The solubility of dipyridamole was determined in a buffer solution (pH = 6.8) containing Eudragit E100 and various concentrations of tartaric acid. Dissolution tests were conducted using a pH-shift method, transitioning from an acidic solution (pH = 1.2) to a buffer solution (pH = 6.8). The drug concentration in the buffer solution was measured to assess drug supersaturation. The dissolution behavior of binary and ternary combinations of dipyridamole, Eudragit E100, and tartaric acid was evaluated and compared. The interference of tartaric acid in the interaction between Eudragit E100 and dipyridamole was assessed using FT-IR and nuclear magnetic resonance (NMR) techniques.

Results

The addition of tartaric acid to Eudragit E100 exhibited a strong synergistic effect in stabilizing the supersaturation of dipyridamole. The results demonstrated that tartaric acid, by lowering the pH, increased the affinity of Eudragit E100 for dipyridamole, thereby enhancing its ability to maintain drug supersaturation.

Conclusion

The presence of acidifiers such as tartaric acid significantly improved the maintenance of drug supersaturation by Eudragit E100 due to the synergistic effect between Eudragit E100 and the acidifier.

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阐明 Eudragit® E100 在酒石酸辅助下维持双嘧达莫过饱和的作用

方法在含有 Eudragit E100 和不同浓度酒石酸的缓冲溶液（pH = 6.8）中测定了双嘧达莫的溶解度。溶解试验采用 pH 值转移法，从酸性溶液（pH = 1.2）过渡到缓冲溶液（pH = 6.8）。通过测量缓冲溶液中的药物浓度来评估药物的过饱和度。评估并比较了双嘧达莫、Eudragit E100 和酒石酸的二元和三元组合的溶解行为。结果在 Eudragit E100 中添加酒石酸对稳定双嘧达莫的过饱和度有很强的协同作用。结果表明，酒石酸通过降低 pH 值，增加了 Eudragit E100 对双嘧达莫的亲和力，从而增强了其维持药物过饱和度的能力。结论由于 Eudragit E100 和酸味剂之间的协同作用，酒石酸等酸味剂的存在显著改善了 Eudragit E100 维持药物过饱和度的能力。

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来源期刊

Journal of Pharmaceutical Innovation PHARMACOLOGY & PHARMACY-

CiteScore

3.70

自引率

3.80%

发文量

审稿时长

>12 weeks

期刊介绍： The Journal of Pharmaceutical Innovation (JPI), is an international, multidisciplinary peer-reviewed scientific journal dedicated to publishing high quality papers emphasizing innovative research and applied technologies within the pharmaceutical and biotechnology industries. JPI''s goal is to be the premier communication vehicle for the critical body of knowledge that is needed for scientific evolution and technical innovation, from R&D to market. Topics will fall under the following categories: Materials science, Product design, Process design, optimization, automation and control, Facilities; Information management, Regulatory policy and strategy, Supply chain developments , Education and professional development, Journal of Pharmaceutical Innovation publishes four issues a year.