Calmodulin and calcium-mediated melatonin signaling mechanisms in plants

IF 2.2 4区 生物学 Q2 PLANT SCIENCES
Dhara Arora, Neha Singh, Satish C. Bhatla
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Abstract

Modulation of melatonin signaling pathway occurs either by direct interaction with calmodulin (CaM) or through regulation of intracellular Ca2+ concentration. Intracellular CaM and CaM-dependent phosphodiesterase (PDE) activity are also possibly modulated by melatonin in vitro through melatonin-CaM interaction. Melatonin acts as a CaM antagonist and modulates CaM-dependent protein phosphorylation, thereby rhythmically regulating cellular functions. Melatonin also acts as a nitric oxide synthase (NOS) inhibitor by interfering with CaM binding to NOS peptide, thereby inhibiting NO biosynthesis. CaM also inhibits the effects of melatonin on cyclic GMP biosynthesis. Melatonin can cause increase in reactive oxygen species (ROS) generation through CaM–mediated activation of phospholipase A2 (PLA2). Thus, the prooxidant action of melatonin is mediated through CaM. Melatonin can directly scavenge ROS species and regulate the activities of various antioxidant enzymes though interaction with CaM. Melatonin causes microtubule depolymerization, thereby affecting cytoskeleton organization in the cells. CaM also inhibits tubulin polymerization. Melatonin is known to regulate photoperiodism and circadian rhythmicity in plants. Both salt stress and melatonin seem to modulate seedling growth by inhibiting CaM-mediated calcium signaling. Upregulation of genes encoding CaM-like protein, calcium-binding protein, calcium-dependent phosphodiesterase and CBL (calcineurin B-like proteins)-interacting protein kinase indicates possible calcium-mediated melatonin signaling in plants.

Abstract Image

植物中的钙调素和钙介导的褪黑激素信号机制
褪黑激素信号通路的调节是通过与钙调素(CaM)直接相互作用或通过调节细胞内 Ca2+ 浓度来实现的。细胞内 CaM 和 CaM 依赖性磷酸二酯酶(PDE)的活性也可能通过褪黑激素与 CaM 的相互作用在体外受到褪黑激素的调节。褪黑激素可作为 CaM 拮抗剂,调节 CaM 依赖性蛋白磷酸化,从而有节奏地调节细胞功能。褪黑素还是一氧化氮合酶(NOS)抑制剂,通过干扰 CaM 与 NOS 肽的结合,从而抑制一氧化氮的生物合成。CaM 还能抑制褪黑激素对环状 GMP 生物合成的影响。褪黑素可通过 CaM 介导的磷脂酶 A2(PLA2)激活作用,导致活性氧(ROS)生成增加。因此,褪黑激素的促氧化作用是通过 CaM 介导的。褪黑激素可直接清除 ROS 物种,并通过与 CaM 的相互作用调节各种抗氧化酶的活性。褪黑激素会导致微管解聚,从而影响细胞内的细胞骨架组织。CaM 还能抑制微管蛋白的聚合。众所周知,褪黑激素能调节植物的光周期和昼夜节律。盐胁迫和褪黑激素似乎都能通过抑制 CaM 介导的钙信号转导来调节幼苗的生长。编码 CaM 样蛋白、钙结合蛋白、钙依赖性磷酸二酯酶和 CBL(钙调素 B 样蛋白)-相互作用蛋白激酶的基因上调表明,植物中可能存在钙介导的褪黑激素信号转导。
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来源期刊
CiteScore
4.20
自引率
7.70%
发文量
32
期刊介绍: The journal does not publish articles in taxonomy, anatomy, systematics and ecology unless they have a physiological approach related to the following sections: Biochemical Processes: primary and secondary metabolism, and biochemistry; Photobiology and Photosynthesis Processes; Cell Biology; Genes and Development; Plant Molecular Biology; Signaling and Response; Plant Nutrition; Growth and Differentiation: seed physiology, hormonal physiology and photomorphogenesis; Post-Harvest Physiology; Ecophysiology/Crop Physiology and Stress Physiology; Applied Plant Ecology; Plant-Microbe and Plant-Insect Interactions; Instrumentation in Plant Physiology; Education in Plant Physiology.
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