Advances in desensitization for human leukocyte antigen incompatible kidney transplantation.

IF 1.8 4区医学 Q3 TRANSPLANTATION

Current Opinion in Organ Transplantation Pub Date : 2023-12-14 DOI:10.1097/mot.0000000000001131

Ashley Vo, Noriko Ammerman, Stanley C Jordan

引用次数: 0

Abstract

Human leukocyte antigen (HLA) sensitization is a major barrier to kidney transplantation induced by exposure to alloantigens through pregnancy, blood product exposure and previous transplantations. Desensitization strategies are undertaken to improve the chances of finding compatible organ offers. Standard approaches to desensitization include the use of plasmapheresis/low dose intravenous immunoglobulin (IVIG) or high dose IVIG plus anti-CD20. However, current methods to reduce HLA antibodies are not always successful, especially in those with calculated panel reactive antibody 99-100%.

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人类白细胞抗原不相容肾移植脱敏疗法的进展。

人类白细胞抗原（HLA）致敏是肾移植的一个主要障碍，其诱因是通过怀孕、接触血液制品和以前的移植手术而暴露于异体抗原。采取脱敏策略是为了增加找到匹配器官的机会。脱敏的标准方法包括使用浆细胞分离/小剂量静脉注射免疫球蛋白（IVIG）或大剂量 IVIG 加抗 CD20。然而，目前减少 HLA 抗体的方法并不总是成功的，尤其是那些计算出的面板反应性抗体为 99-100% 的患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Organ Transplantation 医学-移植

CiteScore

4.10

自引率

4.50%

发文量

124

审稿时长

6-12 weeks

期刊介绍： Current Opinion in Organ Transplantation is an indispensable resource featuring key, up-to-date and important advances in the field from around the world. Led by renowned guest editors for each section, every bimonthly issue of Current Opinion in Organ Transplantation delivers a fresh insight into topics such as stem cell transplantation, immunosuppression, tolerance induction and organ preservation and procurement. With 18 sections in total, the journal provides a convenient and thorough review of the field and will be of interest to researchers, surgeons and other healthcare professionals alike.