Virtual screening and identification of promising therapeutic compounds against drug-resistant Mycobacterium tuberculosis β-ketoacyl-acyl carrier protein synthase I (KasA)

Alexander M. Andrianov, Konstantin V. Furs, Anna V. Gonchar, Alena M. Skrahina, Yixin Wang, Liang-Dong Lyu, Alexander V. Tuzikov
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Abstract

The emergence of new Mycobacterium tuberculosis (Mtb) strains resistant to the key drugs currently used in the clinic for tuberculosis treatment can substantially reduce the probability of therapy ...
虚拟筛选和鉴定针对耐药结核分枝杆菌 β-酮酰-酰基载体蛋白合成酶 I (KasA) 的有前景的治疗化合物
新的结核分枝杆菌(Mtb)菌株对目前临床用于结核病治疗的关键药物具有耐药性,这大大降低了治疗的可能性。
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