Effect of Genetic Polymorphisms on the Pharmacokinetics of Gefitinib in Healthy Chinese Volunteers

IF 1.3 4区医学 Q4 PHARMACOLOGY & PHARMACY

Xenobiotica Pub Date : 2023-12-12 DOI:10.1080/00498254.2023.2294039

Ying-Rong Chen, Xiang Yu, Li-Min Xu, Jue Mei, Meng-Li Tian, Min Xu, Qiu-Yue Jin, Li-Bing Ye, Shui-Xin Yang

引用次数: 0

Abstract

Gefitinib is the first generation drug of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) metabolized by the cytochrome P450 and transported by P-glycoprotein (ABCB1) and br...

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基因多态性对中国健康志愿者服用吉非替尼的药代动力学的影响

吉非替尼是表皮生长因子受体(EGFR)酪氨酸激酶抑制剂(TKI)的第一代药物，由细胞色素P450代谢，p -糖蛋白(ABCB1)和br转运。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Xenobiotica 医学-毒理学

CiteScore

3.80

自引率

5.60%

发文量

审稿时长

2 months

期刊介绍： Xenobiotica covers seven main areas, including:General Xenobiochemistry, including in vitro studies concerned with the metabolism, disposition and excretion of drugs, and other xenobiotics, as well as the structure, function and regulation of associated enzymesClinical Pharmacokinetics and Metabolism, covering the pharmacokinetics and absorption, distribution, metabolism and excretion of drugs and other xenobiotics in manAnimal Pharmacokinetics and Metabolism, covering the pharmacokinetics, and absorption, distribution, metabolism and excretion of drugs and other xenobiotics in animalsPharmacogenetics, defined as the identification and functional characterisation of polymorphic genes that encode xenobiotic metabolising enzymes and transporters that may result in altered enzymatic, cellular and clinical responses to xenobioticsMolecular Toxicology, concerning the mechanisms of toxicity and the study of toxicology of xenobiotics at the molecular levelXenobiotic Transporters, concerned with all aspects of the carrier proteins involved in the movement of xenobiotics into and out of cells, and their impact on pharmacokinetic behaviour in animals and manTopics in Xenobiochemistry, in the form of reviews and commentaries are primarily intended to be a critical analysis of the issue, wherein the author offers opinions on the relevance of data or of a particular experimental approach or methodology