The Molecular Mechanism of Renal Tubulointerstitial Inflammation Promoting Diabetic Nephropathy

IF 2.1 Q2 UROLOGY & NEPHROLOGY
Rui Xue, Haiting Xiao, Vinod Kumar, Xiqian Lan, Ashwani Malhotra, Pravin C. Singhal, Jianning Chen
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Abstract

Abstract Diabetic nephropathy (DN) is a common complication affecting many diabetic patients, leading to end-stage renal disease. However, its pathogenesis still needs to be fully understood to enhance the effectiveness of treatment methods. Traditional theories are predominantly centered on glomerular injuries and need more explicit explanations of recent clinical observations suggesting that renal tubules equally contribute to renal function and that tubular lesions are early features of DN, even occurring before glomerular lesions. Although the conventional view is that DN is not an inflammatory disease, recent studies indicate that systemic and local inflammation, including tubulointerstitial inflammation, contributes to the development of DN. In patients with DN, intrinsic tubulointerstitial cells produce many proinflammatory factors, leading to medullary inflammatory cell infiltration and activation of inflammatory cells in the interstitial region. Therefore, understanding the molecular mechanism of renal tubulointerstitial inflammation contributing to DN injury is of great significance and will help further identify key factors regulating renal tubulointerstitial inflammation in the high glucose environment. This will aid in developing new targets for DN diagnosis and treatment and expanding new DN treatment methods.
肾小管间质炎症促进糖尿病肾病的分子机制
糖尿病肾病(Diabetic nephropathy, DN)是影响许多糖尿病患者的常见并发症,可导致终末期肾脏疾病。然而,其发病机制仍需充分了解,以提高治疗方法的有效性。传统理论主要集中在肾小球损伤上,需要更明确的解释最近的临床观察表明,肾小管同样有助于肾功能,肾小管病变是DN的早期特征,甚至发生在肾小球病变之前。虽然传统观点认为DN不是一种炎症性疾病,但最近的研究表明,全身和局部炎症,包括小管间质炎症,有助于DN的发展。DN患者内生性小管间质细胞产生多种促炎因子,导致髓质炎性细胞浸润,间质区炎性细胞活化。因此,了解肾小管间质炎症导致DN损伤的分子机制具有重要意义,有助于进一步识别高糖环境下调节肾小管间质炎症的关键因素。这将有助于开发新的DN诊断和治疗靶点,并扩大新的DN治疗方法。
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来源期刊
CiteScore
3.90
自引率
5.00%
发文量
40
审稿时长
16 weeks
期刊介绍: International Journal of Nephrology and Renovascular Disease is an international, peer-reviewed, open-access journal focusing on the pathophysiology of the kidney and vascular supply. Epidemiology, screening, diagnosis, and treatment interventions are covered as well as basic science, biochemical and immunological studies. In particular, emphasis will be given to: -Chronic kidney disease- Complications of renovascular disease- Imaging techniques- Renal hypertension- Renal cancer- Treatment including pharmacological and transplantation- Dialysis and treatment of complications of dialysis and renal disease- Quality of Life- Patient satisfaction and preference- Health economic evaluations. The journal welcomes submitted papers covering original research, basic science, clinical studies, reviews & evaluations, guidelines, expert opinion and commentary, case reports and extended reports. The main focus of the journal will be to publish research and clinical results in humans but preclinical, animal and in vitro studies will be published where they shed light on disease processes and potential new therapies and interventions.
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