Anti-cancer activity of novel Schiff base copper (II) complex: synthesis and characterization

IF 0.9 Q4 MATERIALS SCIENCE, MULTIDISCIPLINARY
R. Kothari
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引用次数: 0

Abstract

A novel thiosemicarbazone substituted schiff base ligand and its Cu(II) complex have been prepared and characterized. Schiff bases are considered as an important pro ligand in coordination chemistry because they easily form stable complexes with biologically active transition metal ions. Such as Cu 2+, Zn2+, Ni2+ etc. In this paper, novel Cu (II) complexes of thiosemicarbazone ligands were synthesised by refluxing thiosemicarbazone substituted pro ligands with copper salts in 1:1 molar ratio in absolute ethanol under thermal condition at 80o c for 5-6 hour. The resulting brown coloured copper complexes were filtered and recrystallized from petroleum ether. In this synthesis, we use absolute ethanol as a polar environment for the synthesis of copper complexes from schiff base ligands because the use of polar solvent medium in synthesis plays a very important role in reducing minimum possibilities of side reactions which hinders the proper conversion of ligands into copper complexes and also reducing the reaction time. All synthesized compounds were characterized through various spectroscopic and pharmacological techniques. FT-IR, UVVis, NMR, Mass, TGA-DTA, XRD spectra techniques were used to confirm the structures of copper complexes and ligands. All compounds are thermal stable up to 350o c. The good results of pharmacological activities of compounds like in-vitro anti -oxidant and anti - cancer activity against DPPH and cisplatin drug, explained the presence of biologically active functional groups are present in ligands as well as their copper complexes. Results found that the copper complexes were more active than the ligands. The synthesis of copper complexes from thiosemicarbazone schiff base ligands in proper stoichiometic ratio is an excellent method of preparing pharmacological active compounds which can be considered as good anti -cancer drug candidate for the treatment of cancer.
新型希夫碱铜 (II) 复合物的抗癌活性:合成与表征
制备了一种新型硫代氨基脲取代席夫碱配体及其Cu(II)配合物。希夫碱是配位化学中一种重要的前配体,因为它容易与具有生物活性的过渡金属离子形成稳定的配合物。如cu2 +, Zn2+, Ni2+等。本文用铜盐与硫代氨基脲取代的前配体在无水乙醇中以1:1的摩尔比回流,在80℃条件下加热5 ~ 6小时,合成了新型的硫代氨基脲配体Cu (II)配合物。所得棕色铜配合物经石油醚过滤后再结晶。在本合成中,我们使用无水乙醇作为极性环境,从席夫碱配体合成铜配合物,因为在合成中使用极性溶剂介质对于减少阻碍配体正确转化为铜配合物的副反应的可能性和缩短反应时间起着非常重要的作用。所有合成的化合物都通过各种光谱和药理学技术进行了表征。采用FT-IR、UVVis、NMR、Mass、TGA-DTA、XRD等光谱技术对铜配合物和配体的结构进行了表征。所有化合物在350℃以下均具有热稳定性。化合物的药理活性良好,如体外抗氧化和抗DPPH和顺铂药物的抗癌活性,解释了在配体及其铜配合物中存在生物活性官能团。结果发现铜配合物比配体更有活性。硫代氨基脲基席夫碱配体按适当的化学计量比例合成铜配合物是制备具有药理活性化合物的一种极好的方法,可作为治疗癌症的良好的抗癌候选药物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Optoelectronic and Biomedical Materials
Journal of Optoelectronic and Biomedical Materials MATERIALS SCIENCE, MULTIDISCIPLINARY-
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