Qualitative/Quantitative Analysis of Alcohol and Licit/Illicit Drugs on Post-Mortem Biological Samples from Road Traffic Deaths

IF 2.5 4区工程技术 Q3 CHEMISTRY, ANALYTICAL

Separations Pub Date : 2023-12-01 DOI:10.3390/separations10120589

A. Carfora, A. Feola, Raffaella Petrella, Giusy Ambrosio, S. Festinese, Ilaria Fracassi, Paolo Palermo, Martina Zampone, C. Campobasso

{"title":"Qualitative/Quantitative Analysis of Alcohol and Licit/Illicit Drugs on Post-Mortem Biological Samples from Road Traffic Deaths","authors":"A. Carfora, A. Feola, Raffaella Petrella, Giusy Ambrosio, S. Festinese, Ilaria Fracassi, Paolo Palermo, Martina Zampone, C. Campobasso","doi":"10.3390/separations10120589","DOIUrl":null,"url":null,"abstract":"Alcohol and drug abuse is a major contributory factor of all road deaths in Europe. The aim of this study is to investigate the prevalence of alcohol and licit/illicit drug intake among victims of road accidents in Campania region (Italy). A retrospective analysis of road traffic deaths from 2013 to 2022 in Campania was performed. The toxicological results from fluid samples collected at autopsy were reviewed. In total, 228 road deaths occurred, mostly during nights and weekends. A total of 106 victims tested positive for alcohol and/or drugs, among which 39 (36.8%) tested positive for alcohol only, 27 (25.5%) for alcohol and drugs in association; and 40 (37.7%) for licit/illicit drugs only, either individually or in combination. Polydrug intake has been found in 21 victims, and nine in combination with alcohol. The most detected drugs were cocaine and Δ9THC, followed by benzodiazepines. Blood alcohol concentration (BAC) > 1.5 g/L was found in most alcohol positives, both alone and in association with drugs. Despite the penalties for driving under the influence of alcohol (DUI) and drugs (DUID), no decrease in the number of alcohol and/or drugs related fatal road accidents has been observed. DUI and/or DUID cases were approximately one third of the entire sample study.","PeriodicalId":21833,"journal":{"name":"Separations","volume":" 98","pages":""},"PeriodicalIF":2.5000,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Separations","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.3390/separations10120589","RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}

引用次数: 0

Abstract

Alcohol and drug abuse is a major contributory factor of all road deaths in Europe. The aim of this study is to investigate the prevalence of alcohol and licit/illicit drug intake among victims of road accidents in Campania region (Italy). A retrospective analysis of road traffic deaths from 2013 to 2022 in Campania was performed. The toxicological results from fluid samples collected at autopsy were reviewed. In total, 228 road deaths occurred, mostly during nights and weekends. A total of 106 victims tested positive for alcohol and/or drugs, among which 39 (36.8%) tested positive for alcohol only, 27 (25.5%) for alcohol and drugs in association; and 40 (37.7%) for licit/illicit drugs only, either individually or in combination. Polydrug intake has been found in 21 victims, and nine in combination with alcohol. The most detected drugs were cocaine and Δ9THC, followed by benzodiazepines. Blood alcohol concentration (BAC) > 1.5 g/L was found in most alcohol positives, both alone and in association with drugs. Despite the penalties for driving under the influence of alcohol (DUI) and drugs (DUID), no decrease in the number of alcohol and/or drugs related fatal road accidents has been observed. DUI and/or DUID cases were approximately one third of the entire sample study.

查看原文本刊更多论文

对道路交通事故死亡者死后生物样本中的酒精和合法/非法药物进行定性/定量分析

酒精和药物滥用是造成欧洲所有道路死亡的一个主要因素。这项研究的目的是调查坎帕尼亚地区(意大利)道路交通事故受害者中酒精和合法/非法药物摄入的普遍情况。对坎帕尼亚2013年至2022年道路交通死亡人数进行了回顾性分析。对尸检时收集的液体样本的毒理学结果进行了审查。总共有228人死于交通事故，大多发生在夜间和周末。共有106名受害者酒精和/或毒品检测呈阳性，其中39人(36.8%)仅酒精检测呈阳性，27人(25.5%)酒精和毒品相关检测呈阳性;40人(37.7%)单独或联合使用合法/非法药物。21名受害者服用多种药物，9人同时服用酒精。检出最多的毒品是可卡因和Δ9THC，其次是苯二氮卓类药物。大多数酒精阳性患者血液酒精浓度(BAC) > 1.5 g/L，无论是单独的还是与药物相关的。尽管对酒后驾驶和吸毒驾驶进行了处罚，但与酒精和/或毒品有关的致命道路事故的数量并没有减少。酒驾和/或酒驾病例约占整个样本研究的三分之一。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Separations Chemistry-Analytical Chemistry

CiteScore

3.00

自引率

15.40%

发文量

342

审稿时长

12 weeks

期刊介绍： Separations (formerly Chromatography, ISSN 2227-9075, CODEN: CHROBV) provides an advanced forum for separation and purification science and technology in all areas of chemical, biological and physical science. It publishes reviews, regular research papers and communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. There are, in addition, unique features of this journal: Manuscripts regarding research proposals and research ideas will be particularly welcomed. Electronic files and software regarding the full details of the calculation and experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material. Manuscripts concerning summaries and surveys on research cooperation and projects (that are funded by national governments) to give information for a broad field of users. The scope of the journal includes but is not limited to: Theory and methodology (theory of separation methods, sample preparation, instrumental and column developments, new separation methodologies, etc.) Equipment and techniques, novel hyphenated analytical solutions (significantly extended by their combination with spectroscopic methods and in particular, mass spectrometry) Novel analysis approaches and applications to solve analytical challenges which utilize chromatographic separations as a key step in the overall solution Computational modelling of separations for the purpose of fundamental understanding and/or chromatographic optimization