Tetraeicosahydroxyfullerene C60(ОН)24: optimized preparative synthesis, properties and applica-tions

Abstract

Tetraeicosahydroxyfullerene C60(OH)24 has a wide range of unique and useful properties that allow it to be successfully used in a number of sectors of the national economy. Interest in this compound is due to its extremely high biological potential, which manifests itself in a potentiating effect against malignant neoplasms (when used together with cisplatin) and as an agent for the delivery of radioactive isotopes in radiation medicine. This paper presents a convenient and easily scalable procedure for the synthesis and purification of C60(OH)24 tetraeicosahydroxyfullerene by catalytic bromination of C60 fullerene in liquid bromine in the presence of metallic iron. The technology of purification of the target product using ion exchange resins AB-17-8 and TOKEM-100 has been developed.