Effect of Propofol and Isoflurane on Postoperative Cognitive Dysfunction Following Elective Laminectomy Surgery in Adult Elderly Patients: A Randomized Controlled Trial Study

IF 0.4 Q4 NEUROSCIENCES

Archives of Neuroscience Pub Date : 2023-12-03 DOI:10.5812/ans-132837

Shirin Motaghian, Arash Heroabadi, Keyvan Teymourei Khanesari, Khalil Pestei, Mojtaba Marashi, Reza Atef Yekta

{"title":"Effect of Propofol and Isoflurane on Postoperative Cognitive Dysfunction Following Elective Laminectomy Surgery in Adult Elderly Patients: A Randomized Controlled Trial Study","authors":"Shirin Motaghian, Arash Heroabadi, Keyvan Teymourei Khanesari, Khalil Pestei, Mojtaba Marashi, Reza Atef Yekta","doi":"10.5812/ans-132837","DOIUrl":null,"url":null,"abstract":"Background: Postoperative cognitive dysfunction (POCD) is a significant complication, especially prevalent among elderly individuals following major surgical procedures. Objectives: This study aims to compare the impact of isoflurane and propofol on the occurrence of POCD in patients undergoing elective laminectomy surgery under general anesthesia. Methods: This randomized, double-blind clinical trial took place at Shariati Hospital in Tehran. Patients scheduled for elective laminectomy between December 2020 and November 2021 were enrolled in the study and randomized into 2 groups. Patients in Group P received a Propofol infusion, while patients in Group I were administered isoflurane. Cognitive function assessments were conducted using the Mini-Mental State Examination (MMSE) at 3-time points: Twelve hours before surgery and 6 and 24 hours after surgery. Results: The MMSE scores demonstrated a significant increase in the Propofol group compared to the Isoflurane group at the 6-hour and 24-hour post-surgery time points. However, no significant difference was observed at baseline before surgery (P = 0.04, P = 0.005, and P = 0.2, respectively). Conclusions: These findings suggest that the use of propofol for general anesthesia may be a favorable choice for surgical procedures in elderly patients.","PeriodicalId":43970,"journal":{"name":"Archives of Neuroscience","volume":"36 25","pages":""},"PeriodicalIF":0.4000,"publicationDate":"2023-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Archives of Neuroscience","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5812/ans-132837","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"NEUROSCIENCES","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Postoperative cognitive dysfunction (POCD) is a significant complication, especially prevalent among elderly individuals following major surgical procedures. Objectives: This study aims to compare the impact of isoflurane and propofol on the occurrence of POCD in patients undergoing elective laminectomy surgery under general anesthesia. Methods: This randomized, double-blind clinical trial took place at Shariati Hospital in Tehran. Patients scheduled for elective laminectomy between December 2020 and November 2021 were enrolled in the study and randomized into 2 groups. Patients in Group P received a Propofol infusion, while patients in Group I were administered isoflurane. Cognitive function assessments were conducted using the Mini-Mental State Examination (MMSE) at 3-time points: Twelve hours before surgery and 6 and 24 hours after surgery. Results: The MMSE scores demonstrated a significant increase in the Propofol group compared to the Isoflurane group at the 6-hour and 24-hour post-surgery time points. However, no significant difference was observed at baseline before surgery (P = 0.04, P = 0.005, and P = 0.2, respectively). Conclusions: These findings suggest that the use of propofol for general anesthesia may be a favorable choice for surgical procedures in elderly patients.

查看原文本刊更多论文

异丙酚和异氟醚对成年老年患者选择性椎板切除术后认知功能障碍的影响：随机对照试验研究

背景:术后认知功能障碍(POCD)是重大外科手术后的重要并发症，尤其在老年人中普遍存在。目的:本研究旨在比较异氟醚和异丙酚对全麻下择期椎板切除术患者POCD发生的影响。方法:这项随机、双盲临床试验在德黑兰的沙里亚蒂医院进行。计划在2020年12月至2021年11月期间进行择期椎板切除术的患者被纳入研究，并随机分为两组。P组患者输注异丙酚，I组患者输注异氟醚。采用简易精神状态检查(MMSE)于术前12小时、术后6小时和24小时3个时间点进行认知功能评估。结果:术后6小时和24小时，异氟醚组的MMSE评分明显高于异丙酚组。但术前基线无显著差异(P = 0.04, P = 0.005, P = 0.2)。结论:这些结果提示，使用异丙酚进行全身麻醉可能是老年患者外科手术的一个有利选择。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Archives of Neuroscience NEUROSCIENCES-

自引率

0.00%

发文量

期刊介绍： Archives of neuroscience is a clinical and basic journal which is informative to all practitioners like Neurosurgeons, Neurologists, Psychiatrists, Neuroscientists. It is the official journal of Brain and Spinal Injury Research Center. The Major theme of this journal is to follow the path of scientific collaboration, spontaneity, and goodwill for the future, by providing up-to-date knowledge for the readers. The journal aims at covering different fields, as the name implies, ranging from research in basic and clinical sciences to core topics such as patient care, education, procuring and correct utilization of resources and bringing to limelight the cherished goals of the institute in providing a standard care for the physically disabled patients. This quarterly journal offers a venue for our researchers and scientists to vent their innovative and constructive research works. The scope of the journal is as far wide as the universe as being declared by the name of the journal, but our aim is to pursue our sacred goals in providing a panacea for the intractable ailments, which leave a psychological element in the daily life of such patients. This authoritative clinical and basic journal was founded by Professor Madjid Samii in 2012.