Clinical significance of determining neutrophil extracellular traps in women with oncogynecological neoplasms

Abstract

The formation of neutrophil extracellular traps (NETs), described first in 2004 as a previously unknown neutrophil strategy for combating microbes, has been attracting a growing interest in research community. NETs play a key role in inflammation and infection exploiting effector functions such as degranulation, phagocytosis as well as production of reactive oxygen species (ROS). NETs play a crucial role in defense against systemic infections additionally participating in non-infectious diseases such as inflammation, autoimmune disorders, and cancer.