Expression and significance of IL-17A and IL-22 in children with infectious mononucleosis complicated with liver damage

IF 2.1 4区医学 Q3 VIROLOGY

Future Virology Pub Date : 2023-12-04 DOI:10.2217/fvl-2023-0104

Mengli Xu, Weifang Zhou, Yuewen Su, Meng Cao, Yuqin Li

引用次数: 0

Abstract

Aim: To investigate the expression and clinical significance of IL-17A and IL-22 in the plasma of children with infectious mononucleosis complicated with liver damage caused by Epstein–Barr virus. Method: Peripheral plasma was collected from 64 children with IM. We compared IL-17A, IL-22, the clinical data and laboratory examination indicators between liver damage and non-liver damage groups. Results: We found that the levels of IL-17A and IL-22 were higher in the liver damage group and positively correlated with liver function indicators. CD4+/CD8+ was lower in the liver damage group. Conclusion: The study provides valuable insights into the clinical significance of IL-17A and IL-22 in children with IM complicated with liver damage caused by EBV.

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感染性单核细胞增多症并发肝损伤儿童中 IL-17A 和 IL-22 的表达及其意义

目的:探讨传染性单核细胞增多症合并eb病毒肝损害患儿血浆中IL-17A、IL-22的表达及临床意义。方法:收集64例小儿外周血浆。比较肝损害组与非肝损害组的IL-17A、IL-22、临床资料及实验室检查指标。结果:我们发现肝损害组IL-17A、IL-22水平较高，且与肝功能指标呈正相关。肝损伤组CD4+/CD8+较低。结论:IL-17A和IL-22在IM合并EBV肝损害患儿中的临床意义具有重要意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Future Virology 医学-病毒学

CiteScore

4.00

自引率

3.20%

发文量

审稿时长

6-12 weeks

期刊介绍： Future Virology is a peer-reviewed journal that delivers essential information in concise, at-a-glance article formats. Key advances in the field are reported and analyzed by international experts, providing an authoritative but accessible forum for this ever-expanding area of research. It is an interdisciplinary forum for all scientists working in the field today.