Platelet Microvesicles, Inflammation, and Coagulation Markers: A Pilot Study

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-12-04 DOI:10.3390/hematolrep15040069

A. Gidaro, Alessandro Palmerio Delitala, Roberto Manetti, Sonia Caccia, M. Soloski, Giorgio Lambertenghi Deliliers, D. Castro, Mattia Donadoni, Arianna Bartoli, Giuseppe Sanna, Luigi Bergamaschini, Roberto Castelli

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引用次数: 0

Abstract

Background: Platelet “Microvesicles” (MVs) are studied for their role in blood coagulation and inflammation. The study aimed to establish if MVs are related to age, plasma levels of inflammation, coagulation, and fibrinolysis markers in healthy individuals. Methods: We prospectively enrolled volunteers aged over 18 years. MVs, plasma levels of C-reactive protein (CRP), Interleukin 6 (IL-6), Interleukin 10 (IL-10), Interleukin 17 (IL-17), and transforming growth factor β (TGF-β), fibrinogen, plasminogen activator inhibitor-1 (PAI-1), von Willebrand factor (VWF), homocysteine, factor VII (FVII), thrombin activatable fibrinolysis inhibitor (TAFI), and Protein S were tested. Results: A total of 246 individuals (median age 65 years (“IQR”54–72)) were evaluated. Both univariate analysis and logistic regression models showed that MVs positively correlate with age, CRP, IL-6, IL-10, IL-17, TGF-β, fibrinogen, PAI-1, VWF, FVII, and homocysteine, while inversely correlating with TAFI and Protein S. The ROC curve analysis performed to identify a cut off for MV values (700 kMP) showed a good accuracy with over-range cytokines fibrinolysis factor and coagulation markers. Conclusions: To the best of our knowledge, this study is the first to correlate MVs with an entire panel of cardiovascular risk factors in healthy individuals. A future possible role of MVs in screening exams is suggested.

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血小板微泡、炎症和凝血标志物：一项试点研究

背景:研究血小板“微泡”(MVs)在凝血和炎症中的作用。该研究旨在确定健康人的MVs是否与年龄、血浆炎症水平、凝血和纤溶标志物有关。方法:我们前瞻性地招募年龄在18岁以上的志愿者。检测MVs、血浆c反应蛋白(CRP)、白细胞介素6 (IL-6)、白细胞介素10 (IL-10)、白细胞介素17 (IL-17)、转化生长因子β (TGF-β)、纤维蛋白原、纤溶酶原激活物抑制剂-1 (PAI-1)、血管性血友病因子(VWF)、同型半胱氨酸、因子VII (FVII)、凝血酶活化纤维蛋白溶解抑制剂(TAFI)、蛋白S水平。结果:共评估246例患者(中位年龄65岁(“IQR”54-72))。单因素分析和logistic回归模型均显示，MV与年龄、CRP、IL-6、IL-10、IL-17、TGF-β、纤维蛋白原、PAI-1、VWF、FVII和同型半胱氨酸呈正相关，而与TAFI和Protein s呈负相关。通过ROC曲线分析确定MV值的截断值(700 kMP)，发现MV值与超范围细胞因子、纤溶因子和凝血标志物具有良好的准确性。结论:据我们所知，这项研究是第一个将mv与健康个体的心血管危险因素联系起来的研究。提出了未来mv在筛查检查中的可能作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.