Infusion of Magnetic Nanocatalyst to Microwave Propped Synthesis of Bioactive Azaheterocycles

IF 0.9 Q4 CHEMISTRY, MULTIDISCIPLINARY
Pranali Hadole, Sampat R. Shingda, Aniruddha Mondal, Kundan Lal, R. Chaudhary, Sudip Mondal
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引用次数: 0

Abstract

Microwave-assisted synthesis is a powerful tool in organic chemistry, providing a rapid and efficient method for the synthesis of bioactive heterocycles. The application of microwaves significantly reduces reaction times and increases percentage yields with high purity of the final product. To make the synthetic protocol greener, the application of the magnetic nanocatalyst is a rapidly growing area of interest nowadays. Magnetic nanocatalyst, with its unique features like magnetic separable facile recovery from the reaction media heterogeneously, makes the overall synthetic strategy cleaner, faster, and cost-effective. Aiming this, in the present review, we will focus on the infusion of Magnetic nanocatalyst to microwave-assisted synthesis of various classes of azaheterocyclic compounds, including pyridines, pyrimidines, quinolines, and benzimidazoles. The synthetic methodologies involved in the preparation of these heterocycles are highlighted, along with their biological activities. Furthermore, in this review, the most recent and advanced strategies to incorporate nanocatalysts in the microwave-assisted synthesis of natural products containing azaheterocyclic moieties in drug discovery programs are elucidated in detail, along with the incoming future scope and challenges
将磁性纳米催化剂注入微波支撑的生物活性氮杂环合成中
微波辅助合成是有机化学中一种强有力的工具,为合成具有生物活性的杂环化合物提供了一种快速、高效的方法。微波的应用大大减少了反应时间,提高了最终产品的纯度。为了使合成方案更加环保,磁性纳米催化剂的应用是当今人们感兴趣的一个快速增长的领域。磁性纳米催化剂以其独特的特点,如磁性可分离易于从反应介质中非均质回收,使整体合成策略更清洁,更快速,更具成本效益。为此,本文将重点介绍磁性纳米催化剂在微波辅助下合成各种杂环化合物的研究进展,包括吡啶类、嘧啶类、喹啉类和苯并咪唑类。重点介绍了这些杂环化合物的合成方法及其生物活性。此外,本文还详细阐述了在药物发现计划中,将纳米催化剂纳入微波辅助合成含氮杂环的天然产物的最新和先进策略,以及未来的范围和挑战
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来源期刊
Current Microwave Chemistry
Current Microwave Chemistry CHEMISTRY, MULTIDISCIPLINARY-
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11
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