Relationship between the level of uric acid and peritonitis in peritoneal dialysis patients; a retrospective cohort study

IF 0.2 Q4 UROLOGY & NEPHROLOGY

Journal of Renal Injury Prevention Pub Date : 2023-12-06 DOI:10.34172/jrip.2023.32150

N. Shamspour, Zeinab Jafarian, Maryam Alsadat Mousavi, H. Ahmadipour, Jalal Azmandian

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Abstract

Introduction: Peritonitis is a cause of mortality among peritoneal dialysis (PD) patients. Some studies suggested that uric acid (UC) levels may be effective in inflammatory processes. Objectives: We have examined the relationship between serum UC and peritonitis in PD patients. Patients and Methods: A retrospective cohort study was conducted over six years. The statistical population was all PD patients who underwent PD for at least six months. The sample size included 151 patients based on serum UC levels (less than or equal to 6.5 mg/dL, more than 6.5 mg/dL) and was divided into two groups. Both groups were compared using inflammatory factors and peritonitis. Results: In total, around 100 patients (66.2%) had UC levels ≤6.5 mg/dL, and 51 patients (33.7%) had serum UC levels >6.5 mg/dL. Peritonitis was observed in 72 (47.6%) patients. The frequency of peritonitis in the patients with greater levels of serum UC (51%) was higher compared to the other group (46%), but this difference was not statistically significant (P=0.56). The average hemoglobin level was lower in higher serum UC levels group (P=0.002). The mean levels of serum albumin (P=0.002), phosphorus (P=0.004), and creatinine (P=0.02) were lower in the group with serum UC below 6.5 mg/dL group. Conclusion: There was no correlation discovered between peritonitis and serum UC levels. However, it seems that serum UC can serve as a marker among PD patients to predict the occurrence of anemia and malnutrition.

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腹膜透析患者尿酸水平与腹膜炎之间的关系；一项回顾性队列研究

腹膜炎是腹膜透析(PD)患者死亡的原因之一。一些研究表明尿酸(UC)水平可能在炎症过程中有效。目的:探讨腹膜炎患者血清UC与腹膜炎的关系。患者和方法:一项为期六年的回顾性队列研究。统计人群为所有接受PD治疗至少6个月的PD患者。根据血清UC水平(小于或等于6.5 mg/dL，大于6.5 mg/dL)纳入151例患者，并分为两组。两组用炎症因子和腹膜炎进行比较。结果:UC≤6.5 mg/dL患者约100例(66.2%)，UC >6.5 mg/dL患者约51例(33.7%)。腹膜炎72例(47.6%)。血清UC水平较高的患者腹膜炎发生率(51%)高于另一组(46%)，但差异无统计学意义(P=0.56)。UC水平较高组平均血红蛋白水平较低(P=0.002)。血清UC低于6.5 mg/dL组血清白蛋白(P=0.002)、磷(P=0.004)、肌酐(P=0.02)平均水平较低。结论:腹膜炎与血清UC水平无相关性。然而，血清UC似乎可以作为PD患者贫血和营养不良发生的标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Renal Injury Prevention UROLOGY & NEPHROLOGY-

CiteScore

1.60

自引率

0.00%

发文量

期刊介绍： The Journal of Renal Injury Prevention (JRIP) is a quarterly peer-reviewed international journal devoted to the promotion of early diagnosis and prevention of renal diseases. It publishes in March, June, September and December of each year. It has pursued this aim through publishing editorials, original research articles, reviews, mini-reviews, commentaries, letters to the editor, hypothesis, case reports, epidemiology and prevention, news and views and renal biopsy teaching point. In this journal, particular emphasis is given to research, both experimental and clinical, aimed at protection/prevention of renal failure and modalities in the treatment of diabetic nephropathy. A further aim of this journal is to emphasize and strengthen the link between renal pathologists/nephropathologists and nephrologists. In addition, JRIP welcomes basic biomedical as well as pharmaceutical scientific research applied to clinical nephrology. Futuristic conceptual hypothesis that integrate various fields of acute kidney injury and renal tubular cell protection are encouraged to be submitted.