Association of the cytochrome P450 and arylamine N-acetyltransferase gene polymorphisms with the incidence of head and neck cancer in Polish population

IF 1.4 4区医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

International journal of occupational medicine and environmental health Pub Date : 2023-12-07 DOI:10.13075/ijomeh.1896.02070

Monika Gogolewska, J. Kabziński, Ireneusz Majsterek

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Abstract

Objectives: Head and neck cancer (HNC) is one of the most common cancers. Most exogenous HNC is head and neck squamous cell carcinomas. Scientists are striving to develop diagnostic tests that will allow the prognosis of HNC. The aim of the study was to determine the risk of HNC. The research concerned changes caused by polymorphisms in genes encoding proteins responsible for the metabolism of xenobiotics. Material and Methods: In group of 280 patients with HNC, the occurrence of polymorphic variants in NAT1 (rs72554606), NAT2 (rs1799930), CYP1A (rs1799814), CYP2D (rs3892097) were studied with TaqMan technique. The control group consisted of 260 cancer free people. The TNM scale was analyzed. Gene interactions of genotyped polymorphisms were investigated. The effects of smoking and alcohol consumption on HNC were assessed. Results: The results indicated an increased risk of HNC in NAT1 polymorphisms in the GC genotype (OR = 1.772, 95% CI: 1.184–2.651, p = 0.005) and NAT2 polymorphism in the GA genotype (OR = 1.506, 95% CI: 1.023–2.216, p = 0.037). The protective phenomenon in the CYP1A polymorphism the GT genotype (OR = 0.587, 95% CI: 0.381–0.903, p = 0.015)

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细胞色素 P450 和芳胺 N-乙酰转移酶基因多态性与波兰人头颈癌发病率的关系

目的:头颈癌(HNC)是最常见的肿瘤之一。大多数外源性HNC是头颈部鳞状细胞癌。科学家们正在努力开发诊断测试，以便对HNC进行预测。该研究的目的是确定HNC的风险。该研究涉及由编码负责外源代谢的蛋白质的基因多态性引起的变化。材料与方法:采用TaqMan技术对280例HNC患者的NAT1 (rs72554606)、NAT2 (rs1799930)、CYP1A (rs1799814)、CYP2D (rs3892097)基因多态性变异的发生情况进行研究。对照组由260名无癌症患者组成。对TNM量表进行分析。研究了基因型多态性的基因相互作用。评估吸烟和饮酒对HNC的影响。结果:HNC在GC基因型NAT1多态性(OR = 1.772, 95% CI: 1.184 ~ 2.651, p = 0.005)和GA基因型NAT2多态性(OR = 1.506, 95% CI: 1.023 ~ 2.216, p = 0.037)中的风险增加。CYP1A多态性在GT基因型中的保护性现象(OR = 0.587, 95% CI: 0.381-0.903, p = 0.015)

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来源期刊

International journal of occupational medicine and environmental health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

CiteScore

3.40

自引率

5.00%

发文量

审稿时长

7.5 months

期刊介绍： The Journal is dedicated to present the contemporary research in occupational and environmental health from all over the world. It publishes works concerning: occupational and environmental: medicine, epidemiology, hygiene and toxicology; work physiology and ergonomics, musculoskeletal problems; psychosocial factors at work, work-related mental problems, aging, work ability and return to work; working hours, shift work; reproductive factors and endocrine disruptors; radiation, ionizing and non-ionizing health effects; agricultural hazards; work safety and injury and occupational health service; climate change and its effects on health; omics, genetics and epigenetics in occupational and environmental health; health effects of exposure to nanoparticles and nanotechnology products; human biomarkers in occupational and environmental health, intervention studies, clinical sciences’ achievements with potential to improve occupational and environmental health.